[PDF][PDF] Essential oils enriched self-nano-emulsifying systems for effective oral delivery of Zaleplon for improvement of insomnia treatment
HAA El-Enin, AS Khalifa - Indian Journal of Pharmaceutical Education and …, 2022 - ijper.org
Background: Insomnia is usually associated with mental and physical daytime impairment.
Zaleplon (Zp) is indicated in insomnia management but its limited aqueous solubility led to …
Zaleplon (Zp) is indicated in insomnia management but its limited aqueous solubility led to …
Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric …
The aim of this work is to develop self-nano emulsifying drug delivery system (SNEDDS) to
enhance the oral bioavailability of zaleplon (Zal) as a poorly water-soluble drug. Moreover …
enhance the oral bioavailability of zaleplon (Zal) as a poorly water-soluble drug. Moreover …
Lipid nanoparticles of zaleplon for improved oral delivery by Box–Behnken design: optimization, in vitro and in vivo evaluation
N Dudhipala, KY Janga - Drug development and industrial …, 2017 - Taylor & Francis
Purpose: Zaleplon (ZL) is a hypnotic drug prescribed for the management of insomnia and
convulsions. The oral bioavailability of ZL was low (∼ 30%) owing to poor water solubility …
convulsions. The oral bioavailability of ZL was low (∼ 30%) owing to poor water solubility …
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and …
Based on the administration convenience, transmucosal buccal drug delivery allows special
strength points over peroral routes for systemic delivery. It could achieve local or systemic …
strength points over peroral routes for systemic delivery. It could achieve local or systemic …
Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity
YA Haggag, AK Abosalha… - … & Drug Disposition, 2021 - Wiley Online Library
Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its
potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since …
potent anticonvulsant activity, ZP is not commonly used for the treatment of convulsion since …
The formulation of a nasal nanoemulsion zaleplon in situ gel for the treatment of insomnia
KM Hosny, ZM Banjar - Expert opinion on drug delivery, 2013 - Taylor & Francis
Background: Zaleplon is a drug used for the treatment of insomnia and is available in tablet
form; however, it has two major problems. First, the drug undergoes extensive first pass …
form; however, it has two major problems. First, the drug undergoes extensive first pass …
Brain targeted intranasal zaleplon nano-emulsion: in-vitro characterization and assessment of gamma aminobutyric acid levels in rabbits' brain and plasma at low and …
E Abd-Elrasheed, SN El-Helaly… - Current drug …, 2018 - ingentaconnect.com
Background: Zaleplon is a pyrazolopyrimidin derivative hypnotic drug indicated for the short-
term management of insomnia. Zaleplon belongs to Class II drugs, according to the …
term management of insomnia. Zaleplon belongs to Class II drugs, according to the …
Development of eudragit® s100 based pH-responsive microspheres of zaleplon by spray-drying: tailoring the drug release properties
The aim of this work was to develop Eudragit® S100 (ES100) based pH-responsive
microspheres of zaleplon (ZAL) as a potential delivery system for treatment of an insomnia …
microspheres of zaleplon (ZAL) as a potential delivery system for treatment of an insomnia …
[PDF][PDF] A review of novel formulation strategies to enhance oral delivery of zaleplon
N Dudhipala - J Bioequiv Availab, 2016 - researchgate.net
Zaleplon is a pyrrazolopyrimidine which is recommended for the treatment of insomnia and
pentylenetetrazole/electroshock-induced convulsions is an effective anticonvulsant which …
pentylenetetrazole/electroshock-induced convulsions is an effective anticonvulsant which …
Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability
N Subramanian, SP Sharavanan… - Archives of pharmacal …, 2016 - Springer
Low bioavailability of Lacidipine (LD), an calcium channel blocker pose many challenges in
the treatment of hypertension. The objective of this study was to formulate and characterize …
the treatment of hypertension. The objective of this study was to formulate and characterize …