Background Tobacco use remains the most preventable cause of death; however, its effects
on the brain, and particularly white matter, remain elusive. Previous diffusion tensor imaging …

BACKGROUND: Abnormal macrostructural brain abnormalities in both gray matter and
white matter have been reported in cigarette smokers. However, less is known about white …

Results from recent studies suggest that chronic cigarette smoking is associated with
increased white matter volume in the brain as determined by in vivo neuroimaging. We used …

Previous diffusion tensor imaging (DTI) studies revealed contradictory effects of smoking on
fractional anisotropy (FA). Multiple DTI‐derived indices may help to deduce the …

Individuals who abuse substances often differ from nonusers in their brain structure.
Substance abuse and addiction is often associated with atrophy and pathology of grey …

Background We previously reported widespread microstructural deficits of brain white matter
in alcohol-dependent individuals (ALC) compared to light drinkers in a small 1.5 T diffusion …

Rationale Diffusion tensor imaging has been used before in testing associations between
cigarette smoking and white matter integrity, with inconsistent results. Published reports …

Objectives: Fractional anisotropy (FA) via diffusion tensor imaging (DTI) can quantify the
white matter integrity. Exposure to addictive drugs, such as alcohol, cocaine …

Previous brain imaging studies with chronic cocaine users (CU) using diffusion tensor
imaging (DTI) mostly focused on fractional anisotropy to investigate white matter (WM) …

Background Diffusion tensor imaging (DTI) is a useful technique for non-invasively
investigating the microstructural organization of white matter (WM), and the most consistent …