Role of xenobiotics in the induction and progression of fatty liver disease
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …
The mechanistic basis for the induction of hepatic steatosis by xenobiotics
DE Amacher - Expert opinion on drug metabolism & toxicology, 2011 - Taylor & Francis
Introduction: Hepatic steatosis is the histological observation of numerous lipid inclusions
due to an excess accumulation of triacylglycerols. They are a concern with new therapeutic …
due to an excess accumulation of triacylglycerols. They are a concern with new therapeutic …
Putative mechanisms of environmental chemical–induced steatosis
JP Kaiser, JC Lipscomb… - International journal of …, 2012 - journals.sagepub.com
Liver disease is a major health issue characterized by several pathological changes, with
steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of …
steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of …
Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
K Nagata, H Suzuki, S Sakaguchi - The Journal of toxicological …, 2007 - jstage.jst.go.jp
This review showed the common pathogenic mechanism in the development of non-
alcoholic or alcoholic steatohepatitis. In particular, we describe the role of innate immune …
alcoholic or alcoholic steatohepatitis. In particular, we describe the role of innate immune …
The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis
MS Sozio, S Liangpunsakul… - Seminars in liver …, 2010 - thieme-connect.com
Hepatic steatosis is now understood to play an important role in the development of
advanced liver disease. Alcoholic and nonalcoholic fatty liver each begin with the …
advanced liver disease. Alcoholic and nonalcoholic fatty liver each begin with the …
[HTML][HTML] Xenobiotic-induced aggravation of metabolic-associated fatty liver disease
J Massart, K Begriche, A Corlu, B Fromenty - International Journal of …, 2022 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD), which is often linked to obesity,
encompasses a large spectrum of hepatic lesions, including simple fatty liver …
encompasses a large spectrum of hepatic lesions, including simple fatty liver …
Identification of environmental chemicals associated with the development of toxicant-associated fatty liver disease in rodents
L Al-Eryani, B Wahlang, KC Falkner… - Toxicologic …, 2015 - journals.sagepub.com
Background: Toxicant-associated fatty liver disease (TAFLD) is a recently identified form of
nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals …
nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals …
Fat and the liver--a molecular overview.
SA Harrison, AM Diehl - Seminars in gastrointestinal disease, 2002 - europepmc.org
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that occurs in nondrinkers
but which cannot be distinguished from alcohol-induced liver disease histologically. There …
but which cannot be distinguished from alcohol-induced liver disease histologically. There …
Hepatotoxicity: mechanisms of liver injury
MG Neuman - Liver diseases: a multidisciplinary textbook, 2020 - Springer
Toxic liver disease, hepatotoxicity, encompasses numerous different individual diseases that
ultimately lead to progressive damage of the liver, to liver malfunction and death …
ultimately lead to progressive damage of the liver, to liver malfunction and death …
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
D Wang, Y Wei, MJ Pagliassotti - Endocrinology, 2006 - academic.oup.com
Nonalcoholic fatty liver disease is a relatively new hepatic sequela of obesity and type 2
diabetes. The pathogenesis of liver injury and disease progression in nonalcoholic fatty liver …
diabetes. The pathogenesis of liver injury and disease progression in nonalcoholic fatty liver …