Role of xenobiotics in the induction and progression of fatty liver disease

JE Klaunig, X Li, Z Wang - Toxicology research, 2018 - academic.oup.com
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …

The mechanistic basis for the induction of hepatic steatosis by xenobiotics

DE Amacher - Expert opinion on drug metabolism & toxicology, 2011 - Taylor & Francis
Introduction: Hepatic steatosis is the histological observation of numerous lipid inclusions
due to an excess accumulation of triacylglycerols. They are a concern with new therapeutic …

Putative mechanisms of environmental chemical–induced steatosis

JP Kaiser, JC Lipscomb… - International journal of …, 2012 - journals.sagepub.com
Liver disease is a major health issue characterized by several pathological changes, with
steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of …

Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis

K Nagata, H Suzuki, S Sakaguchi - The Journal of toxicological …, 2007 - jstage.jst.go.jp
This review showed the common pathogenic mechanism in the development of non-
alcoholic or alcoholic steatohepatitis. In particular, we describe the role of innate immune …

The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis

MS Sozio, S Liangpunsakul… - Seminars in liver …, 2010 - thieme-connect.com
Hepatic steatosis is now understood to play an important role in the development of
advanced liver disease. Alcoholic and nonalcoholic fatty liver each begin with the …

[HTML][HTML] Xenobiotic-induced aggravation of metabolic-associated fatty liver disease

J Massart, K Begriche, A Corlu, B Fromenty - International Journal of …, 2022 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD), which is often linked to obesity,
encompasses a large spectrum of hepatic lesions, including simple fatty liver …

Identification of environmental chemicals associated with the development of toxicant-associated fatty liver disease in rodents

L Al-Eryani, B Wahlang, KC Falkner… - Toxicologic …, 2015 - journals.sagepub.com
Background: Toxicant-associated fatty liver disease (TAFLD) is a recently identified form of
nonalcoholic fatty liver disease (NAFLD) associated with exposure to industrial chemicals …

Fat and the liver--a molecular overview.

SA Harrison, AM Diehl - Seminars in gastrointestinal disease, 2002 - europepmc.org
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that occurs in nondrinkers
but which cannot be distinguished from alcohol-induced liver disease histologically. There …

Hepatotoxicity: mechanisms of liver injury

MG Neuman - Liver diseases: a multidisciplinary textbook, 2020 - Springer
Toxic liver disease, hepatotoxicity, encompasses numerous different individual diseases that
ultimately lead to progressive damage of the liver, to liver malfunction and death …

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

D Wang, Y Wei, MJ Pagliassotti - Endocrinology, 2006 - academic.oup.com
Nonalcoholic fatty liver disease is a relatively new hepatic sequela of obesity and type 2
diabetes. The pathogenesis of liver injury and disease progression in nonalcoholic fatty liver …