The methylome is subject to genetic and environmental effects. Their impact may depend on
sex and age, resulting in sex-and age-related physiological variation and disease …

Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …

Background Despite the important role DNA methylation plays in transcriptional regulation,
the transgenerational inheritance of DNA methylation is not well understood. The genetic …

Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …

Populations are often divided categorically into distinct racial/ethnic groups based on social
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …

Epigenetic mechanisms such as DNA methylation (DNAm) are essential for regulation of
gene expression. DNAm is dynamic, influenced by both environmental and genetic factors …

Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …

Background Epigenome-wide association studies of human disease and other quantitative
traits are becoming increasingly common. A series of papers reporting age-related changes …

Epigenetic changes are required for normal development, yet the nature and respective
contribution of factors that drive epigenetic variation in humans remain to be fully …

Epigenomics regulates gene expression and is as important as genomics in precision
personal health, as it is heavily influenced by environment and lifestyle. We profiled whole …