Contaminants, such as nucleic acids or toxic small molecules, threaten both human health
and ecosystems when they infiltrate the environment. The precise and highly sensitive …

Methods that enable rapid, sensitive and specific analyses of nucleic acid sequences have
positive effects on precise disease diagnostics and effective clinical treatments by providing …

Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been
utilized in biosensing applications. The recent discovery of the collateral RNA cleavage …

Accurate and rapid detection of pathogens is essential for food safety, epidemic prevention,
disease diagnosis and environmental monitoring. So far, many CRISPR/Cas systems have …

The groundbreaking gene-editing mechanism, CRISPR (Clustered Regularly Interspaced
Short Palindromic Repeats), paired with the protein Cas9, has significantly advanced the …

The increasing needs for developing biosensors for various applications in infectious
disease diagnosis, environmental monitoring, and food safety put forth challenges on sensor …

The clustered regularly interspaced short palindromic repeats (CRISPR) system is a natural
adaptive immune system of prokaryotes. The CRISPR-Cas system is currently divided into …

Background The integration of CRISPR-Cas systems and surface-enhanced Raman
spectroscopy (SERS) has emerged as a powerful approach for developing highly sensitive …

Biosensing based on CRISPR-Cas systems is a young but rapidly evolving technology. The
unprecedented properties of the CRISPR-Cas system provide an innovative tool for …

Conventional and routine diagnostics such as polymerase chain reaction (PCR) and
serological tests are less sensitive, costly, and require sample pretreatment procedures …