Recent studies have documented that remote organs are affected by ischemic injury to the
kidney. Here we studied whether the liver also suffers damage during induction of renal …

Ischemia‐reperfusion is a common cause for acute kidney injury and can lead to distant
organ dysfunction. Glutathione is a major endogenous antioxidant and its depletion directly …

Liver ischemia/reperfusion has been shown to result in injury of remote organs such as the
heart and lungs. Whether or not acute liver injury also results in kidney injury has so far not …

Background In the past years evidence has been growing about the interconnection of
chronic kidney disease and acute kidney injury. The underlying pathophysiological …

Oxygen free radicals have been implicated as mediators of ischemia/reperfusion injury in a
variety of organs. We investigated the role of oxidative injury and endogenous hepatic …

Oxidative stress is an important factor in many pathological conditions such as inflammation,
cancer, ageing and organ response to ischemia‐reperfusion. Humans have developed a …

Background. Ischemia/reperfusion (I/R) injury induces an inflammatory response and
production of reactive oxygen species (ROS), which affects the organs remote to the sites of …

Renal ischemia and reperfusion have been shown to be associated with an enhanced renal
lipid peroxidation. Because glutathione (GSH) serves to protect cells from oxidative stress …

Nitric oxide is known to modulate intracellular glutathione levels, but the relationship
between nitric oxide synthesis and glutathione metabolism during endotoxemia is unknown …

Hepatic ischemia reperfusion (IR) is the leading cause of acute liver failure (ALF) during the
perioperative period and patients with ALF frequently develop acute kidney injury (AKI) …