BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus

RJ Tolwani, PS Buckmaster, S Varma, JM Cosgaya… - Neuroscience, 2002 - Elsevier
There is increasing evidence that brain-derived neurotrophic factor (BDNF) modulates
synaptic and morphological plasticity in the developing and mature nervous system …

Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal …

B Singh, C Henneberger, D Betances… - Journal of …, 2006 - Soc Neuroscience
Cultured neurons from bdnf−/− mice display reduced densities of synaptic terminals,
although in vivo these deficits are small or absent. Here we aimed at clarifying the local …

Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites

JA Gorski, SR Zeiler, S Tamowski… - Journal of …, 2003 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival,
migration, morphological and biochemical differentiation, and modulation of synaptic …

Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant …

SC Danzer, KRC Crooks, DC Lo… - Journal of …, 2002 - Soc Neuroscience
During limbic epileptogenesis in vivo the dentate granule cells (DGCs) exhibit increased
expression of brain-derived neurotrophic factor (BDNF), followed by striking morphologic …

Autocrine action of BDNF on dendrite development of adult-born hippocampal neurons

L Wang, X Chang, L She, D Xu, W Huang… - Journal of …, 2015 - Soc Neuroscience
Dendrite development of newborn granule cells (GCs) in the dentate gyrus of adult
hippocampus is critical for their incorporation into existing hippocampal circuits, but the …

The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity

Y Kellner, N Gödecke, T Dierkes, N Thieme… - Frontiers in Synaptic …, 2014 - frontiersin.org
The fine tuning of neural networks during development and learning relies upon both
functional and structural plastic processes. Changes in the number as well as in the size and …

Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth

S Rauskolb, M Zagrebelsky, A Dreznjak… - Journal of …, 2010 - Soc Neuroscience
Although brain-derived neurotrophic factor (BDNF) is linked with an increasing number of
conditions causing brain dysfunction, its role in the postnatal CNS has remained difficult to …

BDNF regulates primary dendrite formation in cortical neurons via the PI3‐kinase and MAP kinase signaling pathways

PA Dijkhuizen, A Ghosh - Journal of neurobiology, 2005 - Wiley Online Library
Neurotrophins are known to regulate dendritic development, but the mechanisms that
mediate neurotrophin‐dependent dendrite formation are largely unknown. Here we show …

Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5

MJ Wirth, A Brün, J Grabert, S Patz, P Wahle - 2003 - journals.biologists.com
Neurotrophins are candidate molecules for regulating dendritogenesis. We report here on
dendritic growth of rat visual cortex pyramidal and interneurons overexpressingbrain …

Local effects of BDNF on dendritic growth

HW Horch - Reviews in the neurosciences, 2004 - degruyter.com
The development of dendrites is a crucial step in the formation of cortical circuitry. The
niorphogen brain-derived neurotrophic factor (BDNF) may mediate the effects of activity on …