Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: Possible cannabinoid …

JA Bilbrey, YT Ortiz, JS Felix, LR McMahon… - …, 2022 - Springer
Pain is one of the most common reasons to seek medical attention, and chronic pain is a
worldwide epidemic. Anecdotal reports suggest cannabis may be an effective analgesic. As …

Oral efficacy of Δ (9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model

VA Mitchell, J Harley, SL Casey, AC Vaughan… - …, 2021 - Elsevier
The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …

Role of cannabinoids and terpenes in cannabis-mediated analgesia in rats

HM Harris, MA Rousseau, AS Wanas… - Cannabis and …, 2019 - liebertpub.com
Introduction: Cannabis sativa has been used for centuries in treating pain. However, the
analgesic role of many of its constituents including terpenes is unknown. This research …

THC and gabapentin interactions in a mouse neuropathic pain model

N Atwal, SL Casey, VA Mitchell, CW Vaughan - Neuropharmacology, 2019 - Elsevier
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …

Cannabis constituent synergy in a mouse neuropathic pain model

SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …

[HTML][HTML] Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model

A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …

Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception

L Booker, PS Naidu, RK Razdan, A Mahadevan… - Drug and alcohol …, 2009 - Elsevier
Considerable preclinical research has demonstrated the efficacy of Δ9-tetrahydrocannabinol
(Δ9-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of …

Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis

CEB Rodriguez, L Ouyang… - Behavioural …, 2022 - journals.lww.com
Cannabis has been used for centuries for its medicinal properties. Given the dangerous and
unpleasant side effects of existing analgesics, the chemical constituents of Cannabis have …

[HTML][HTML] Amygdala activity contributes to the dissociative effect of cannabis on pain perception

MC Lee, M Ploner, K Wiech, U Bingel, V Wanigasekera… - PAIN®, 2013 - Elsevier
Cannabis is reported to be remarkably effective for the relief of otherwise intractable pain.
However, the bases for pain relief afforded by this psychotropic agent are debatable …

[HTML][HTML] The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic …

AL Klauke, I Racz, B Pradier, A Markert… - European …, 2014 - Elsevier
The widespread plant volatile beta-caryophyllene (BCP) was recently identified as a natural
selective agonist of the peripherally expressed cannabinoid receptor 2 (CB 2). It is found in …