Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: Possible cannabinoid …
JA Bilbrey, YT Ortiz, JS Felix, LR McMahon… - …, 2022 - Springer
Pain is one of the most common reasons to seek medical attention, and chronic pain is a
worldwide epidemic. Anecdotal reports suggest cannabis may be an effective analgesic. As …
worldwide epidemic. Anecdotal reports suggest cannabis may be an effective analgesic. As …
Oral efficacy of Δ (9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model
VA Mitchell, J Harley, SL Casey, AC Vaughan… - …, 2021 - Elsevier
The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …
Role of cannabinoids and terpenes in cannabis-mediated analgesia in rats
HM Harris, MA Rousseau, AS Wanas… - Cannabis and …, 2019 - liebertpub.com
Introduction: Cannabis sativa has been used for centuries in treating pain. However, the
analgesic role of many of its constituents including terpenes is unknown. This research …
analgesic role of many of its constituents including terpenes is unknown. This research …
THC and gabapentin interactions in a mouse neuropathic pain model
N Atwal, SL Casey, VA Mitchell, CW Vaughan - Neuropharmacology, 2019 - Elsevier
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …
Cannabis constituent synergy in a mouse neuropathic pain model
SL Casey, N Atwal, CW Vaughan - Pain, 2017 - journals.lww.com
Cannabis and its psychoactive constituent D9-tetrahydrocannabinol (THC) have efficacy
against neuropathic pain, however, this is hampered by their side effects. It has been …
against neuropathic pain, however, this is hampered by their side effects. It has been …
[HTML][HTML] Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model
A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …
Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception
L Booker, PS Naidu, RK Razdan, A Mahadevan… - Drug and alcohol …, 2009 - Elsevier
Considerable preclinical research has demonstrated the efficacy of Δ9-tetrahydrocannabinol
(Δ9-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of …
(Δ9-THC), the primary psychoactive constituent of Cannabis sativa, in a wide variety of …
Antinociceptive effects of minor cannabinoids, terpenes and flavonoids in Cannabis
CEB Rodriguez, L Ouyang… - Behavioural …, 2022 - journals.lww.com
Cannabis has been used for centuries for its medicinal properties. Given the dangerous and
unpleasant side effects of existing analgesics, the chemical constituents of Cannabis have …
unpleasant side effects of existing analgesics, the chemical constituents of Cannabis have …
[HTML][HTML] Amygdala activity contributes to the dissociative effect of cannabis on pain perception
Cannabis is reported to be remarkably effective for the relief of otherwise intractable pain.
However, the bases for pain relief afforded by this psychotropic agent are debatable …
However, the bases for pain relief afforded by this psychotropic agent are debatable …
[HTML][HTML] The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic …
AL Klauke, I Racz, B Pradier, A Markert… - European …, 2014 - Elsevier
The widespread plant volatile beta-caryophyllene (BCP) was recently identified as a natural
selective agonist of the peripherally expressed cannabinoid receptor 2 (CB 2). It is found in …
selective agonist of the peripherally expressed cannabinoid receptor 2 (CB 2). It is found in …