Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …

Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral
tolerance therefore, they are key in preventing excessive immune responses and …

Organ transplantation is widely acknowledged as the best option for end stage failure of vital
organs. Long-term graft survival is however limited by graft rejection, a destructive process …

Solid organ transplantation is the treatment of choice for patients with end-stage organ
dysfunction. Despite improvements in short-term outcome, long-term outcome is suboptimal …

The concept of regulatory T cell (Treg) therapy in transplantation is now a reality. Significant
advances in science and technology have enabled us to isolate human Tregs, expand them …

The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …

The major challenge in transplantation medicine remains long-term allograft acceptance,
with preserved allograft function under minimal chronic immunosuppression. To safely …

Current clinical strategies to control the alloimmune response after transplantation do not
fully prevent induction of the immunological processes which lead to acute and chronic …

Owing to the adverse effects of immunosuppression and an inability to prevent chronic
rejection, there is a pressing need for alternative strategies to control alloimmunity. In three …

Numerous preclinical studies have provided solid evidence supporting adoptive transfer of
regulatory T cells (Tregs) to induce organ tolerance. As a result, there are 7 currently active …