DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …

DNA methylation plays an integral role in development and aging through epigenetic
regulation of genome function. DNA methyltransferase 1 (Dnmt1) is the most prevalent DNA …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and
function, during normal and pathological brain development and aging remains unclear …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …

Aging, which is accompanied by decreased organ function and increased disease
incidence, limits human lifespan and has attracted investigators for thousands of years. In …

The biochemistry of aging is complex, with biologically significant changes occurring in
proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Gene expression is modulated by epigenetic factors that come in varying forms, such as
DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent …