Oxidative stress pathways involved in cytotoxicity and genotoxicity of titanium dioxide (TiO2) nanoparticles on cells constitutive of alveolo-capillary barrier in vitro

M Hanot-Roy, E Tubeuf, A Guilbert, A Bado-Nilles… - Toxicology in vitro, 2016 - Elsevier
The health risks of nanoparticles remain a serious concern given their prevalence from
industrial and domestic use. The primary route of titanium dioxide nanoparticle exposure is …

Evaluation of cytotoxic, genotoxic and inflammatory response in human alveolar and bronchial epithelial cells exposed to titanium dioxide nanoparticles

CL Ursini, D Cavallo, AM Fresegna… - Journal of Applied …, 2014 - Wiley Online Library
The toxicity of titanium dioxide nanoparticles (TiO2‐NPs), used in several applications,
seems to be influenced by their specific physicochemical characteristics. Cyto‐genotoxic …

Nano-titanium dioxide induces genotoxicity and apoptosis in human lung cancer cell line, A549

RK Srivastava, Q Rahman… - Human & …, 2013 - journals.sagepub.com
The increased inhaled application of titanium dioxide nanoparticles (TiO2 NPs) increases
the potential pulmonary health risks. The present investigations were carried out to study the …

Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents

L Armand, A Tarantini, D Beal, M Biola-Clier… - …, 2016 - Taylor & Francis
Abstract Titanium dioxide nanoparticles (TiO2-NPs) are one of the most produced NPs in the
world. Their toxicity has been studied for a decade using acute exposure scenarios, ie high …

Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells

EJ Park, J Yi, KH Chung, DY Ryu, J Choi, K Park - Toxicology letters, 2008 - Elsevier
As the applications of industrial nanoparticles are being developed, the concerns on the
environmental health are increasing. Cytotoxicities of titanium dioxide nanoparticles of …

[HTML][HTML] Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

K Bhattacharya, M Davoren, J Boertz… - Particle and fibre …, 2009 - Springer
Abstract Titanium dioxide (TiO 2), also known as titanium (IV) oxide or anatase, is the
naturally occurring oxide of titanium. It is also one of the most commercially used form. To …

Exploration of cytotoxic and genotoxic endpoints following sub-chronic oral exposure to titanium dioxide nanoparticles

S Chakrabarti, D Goyary, S Karmakar… - Toxicology and …, 2019 - journals.sagepub.com
Health hazards of titanium dioxide nanoparticles (TiO2-NPs) have raised severe concerns
because of the paucity of information regarding the toxic effects among the population. In the …

[HTML][HTML] DNA oxidative damage as a sensitive genetic endpoint to detect the genotoxicity induced by titanium dioxide nanoparticles

Z Chen, J Shi, Y Zhang, S Han, J Zhang, G Jia - Nanomaterials, 2022 - mdpi.com
The genotoxicity of nanomaterials has attracted great attention in recent years. As a possible
occupational carcinogen, the genotoxic effects and underlying mechanisms of titanium …

Oxidative stress-induced cytotoxic and genotoxic effects of nano-sized titanium dioxide particles in human HaCaT keratinocytes

A Jaeger, DG Weiss, L Jonas, R Kriehuber - Toxicology, 2012 - Elsevier
Since nano-sized particles (NPs) are increasingly used in various fields of innovative
biomedicine and industrial technologies, it is of importance to identify their potential human …

Effect of treatment media on the agglomeration of titanium dioxide nanoparticles: impact on genotoxicity, cellular interaction, and cell cycle

RY Prasad, K Wallace, KM Daniel, AH Tennant… - ACS …, 2013 - ACS Publications
The widespread use of titanium dioxide (TiO2) nanoparticles in consumer products
increases the probability of exposure to humans and the environment. Although TiO2 …