The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease
SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …
Involvement of p38 MAPK in synaptic function and dysfunction
C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …
Targeting p38 MAPK pathway for the treatment of Alzheimer's disease
L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …
Recent advances in the inhibition of p38 MAPK as a potential strategy for the treatment of Alzheimer's disease
P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …
The role of mitogen-activated protein kinase pathways in Alzheimer's disease
Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …
[HTML][HTML] The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS
AD Bachstetter, LJ Van Eldik - Aging and disease, 2010 - ncbi.nlm.nih.gov
Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system
K Takeda, H Ichijo - Genes to Cells, 2002 - Wiley Online Library
p38 mitogen‐activated protein kinases (MAPKs), together with extracellular signal‐regulated
kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs), constitute the MAPK family. Multiple …
kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs), constitute the MAPK family. Multiple …
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
Background Hyperphosphorylation and aggregation of tau protein are the pathological
hallmarks of Alzheimer's disease and related tauopathies. We previously demonstrated that …
hallmarks of Alzheimer's disease and related tauopathies. We previously demonstrated that …
Role of p38/MAPKs in Alzheimer's disease: implications for amyloid beta toxicity targeted therapy
A myriad of environmental and genetic factors, as well as the physiologic process of aging,
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
contribute to Alzheimer's disease (AD) pathology. Neuroinflammation is and has been a …
p38 MAP kinase inhibitors as potential therapeutic drugs for neural diseases
S Yasuda, H Sugiura, H Tanaka… - … System Agents in …, 2011 - ingentaconnect.com
Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by various cellular
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …