[HTML][HTML] Parkinson's disease: mechanisms and models
W Dauer, S Przedborski - Neuron, 2003 - cell.com
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …
Neuronal pathology in Parkinson's disease
JB Schulz, BH Falkenburger - Cell and tissue research, 2004 - Springer
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra leading to the major clinical and pharmacological abnormalities of …
in the substantia nigra leading to the major clinical and pharmacological abnormalities of …
Parkinson disease: from pathology to molecular disease mechanisms
DT Dexter, P Jenner - Free Radical Biology and Medicine, 2013 - Elsevier
Parkinson disease (PD) is a complex neurodegenerative disorder with both motor and
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …
nonmotor symptoms owing to a spreading process of neuronal loss in the brain. At present …
Molecular pathogenesis of Parkinson's disease
S Gandhi, NW Wood - Human molecular genetics, 2005 - academic.oup.com
Parkinson's disease (PD) is a common and incurable neurodegenerative disease, affecting
1% of the population over the age of 65. Despite a well-described clinical and pathological …
1% of the population over the age of 65. Despite a well-described clinical and pathological …
Neuroprotection and dopamine agonists
AHV Schapira - Neurology, 2002 - AAN Enterprises
Several factors are known to be capable of inducing relatively selective dopaminergic cell
death in the substantia nigra and inducing the clinical features that characterize Parkinson's …
death in the substantia nigra and inducing the clinical features that characterize Parkinson's …
Molecular pathophysiology of Parkinson's disease
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …
Toxin models of mitochondrial dysfunction in Parkinson's disease
TN Martinez, JT Greenamyre - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parkinson's disease (PD) is a neurodegenerative disorder characterized, in
part, by the progressive and selective loss of dopaminergic neuron cell bodies within the …
part, by the progressive and selective loss of dopaminergic neuron cell bodies within the …
[HTML][HTML] Parkinson's disease: animal models and dopaminergic cell vulnerability
J Blesa, S Przedborski - Frontiers in neuroanatomy, 2014 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …
[HTML][HTML] Parkinson's disease: from causes to mechanisms
O Corti, C Hampe, F Darios, P Ibanez, M Ruberg… - Comptes rendus …, 2005 - Elsevier
Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease
of unknown etiology. Environmental factors have long been suspected to participate in the …
of unknown etiology. Environmental factors have long been suspected to participate in the …
Neuroinflammation and oxidative stress: co-conspirators in the pathology of Parkinson's disease
Parkinson's disease (PD) is a complex disease, with genetics and environment contributing
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …
to the disease onset. Recent studies of causative PD genes have confirmed the involvement …