Several factors have been recognized as possible triggers of ventilator-induced lung injury
(VILI). The first is pressure (thus the 'barotrauma'), then the volume (hence the 'volutrauma') …

Despite over 40 years of research, there is no specific lung-directed therapy for the acute
respiratory distress syndrome (ARDS). Although much has evolved in our understanding of …

Ventilation is inherently a dynamic process. The present-day clinical practice of
concentrating on the static inflation characteristics of the individual tidal cycle (plateau …

Although mechanical ventilation (MV) is a life-saving intervention for patients with acute
respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as …

Mechanical ventilation is a life-supportive therapy, but can also promote damage to
pulmonary structures, such as epithelial and endothelial cells and the extracellular matrix, in …

Despite being a promising idea that combines several variables related to ventilator-induced
lung injury (VILI), the concept of mechanical power (MP) carries a number of limitations …

Background The ventilator works mechanically on the lung parenchyma. The authors set out
to obtain the proof of concept that ventilator-induced lung injury (VILI) depends on the …

Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

Our current understanding of protective measures for avoiding ventilator-induced lung injury
(VILI) has evolved from targeting low tidal volumes to lowering plateau and driving pressure …

Mechanical ventilation is a life-support system used to ensure blood gas exchange and to
assist the respiratory muscles in ventilating the lung during the acute phase of lung disease …