Vitamin D shows a variety of pleiotropic activities which cannot be fully explained by the
stimulation of classic pathway-and vitamin D receptor (VDR)-dependent transcriptional …

It took several hundred million years of evolution, in order to develop the endocrine vitamin
D signaling system, which is formed by a nuclear receptor, the transcription factor VDR …

Vitamin D3 is synthesized in the skin during summer under the influence of ultraviolet light of
the sun, or it is obtained from food, especially fatty fish. After hydroxylation in the liver into 25 …

Background: At sufficient sun exposure, humans can synthesize vitamin D3 endogenously in
their skin, but today's lifestyle makes the secosteroid a true vitamin that needs to be taken up …

Vitamin D is a molecule displaying an important physiological impact. Average human diet is
neither rich in vitamin D2 (of plant origin) nor in vitamin D3 (of animal origin). Therefore …

Nutrigenomics attempts to characterize and integrate the relation between dietary molecules
and gene expression on a genome-wide level. One of the biologically active nutritional …

Since its discovery in 1920, a great deal of effort has gone into investigating the
physiological actions of vitamin D and the impact its deficiency has on human health …

Although vitamin D was initially considered a nutrient, it has been recognized that the
molecules derived from vitamin D metabolism are best considered as a complex endocrine …

The vitamin D3 metabolite 1α, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] is the exclusive high-
affinity ligand of the vitamin D receptor (VDR), a transcription factor with direct effects on …

Epigenetic mechanisms play a crucial role in regulating gene expression. The main
mechanisms involve methylation of DNA and covalent modifications of histones by …