Rheumatoid arthritis (RA) is the most common auto-immune disease (Nishimoto and
Kishimoto, 2004), affecting 1% of the population (McInnes and Schett, 2007). Despite this …

Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease. It preferentially
targets diarthrodial joints but displays comorbidities in other organs, such as the respiratory …

Electrical excitation of peripheral somatosensory nerves is a first step in generation of most
pain signals in mammalian nervous system. Such excitation is controlled by an intricate set …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …

Rheumatoid arthritis synovial fibroblasts (RA‐SFs) show an aggressive phenotype and
support joint inflammation and tissue destruction. New druggable targets in RA‐SFs would …

K channels are present in all the cells and maintain resting membrane potentials. Closing of
K channel leads to depolarisation. Voltage-gated K channels: get activated by the change in …

There is a long-sought need for superior pharmacotherapy of pain syndromes. Although
universal enhancement of K+ channel function in the periphery can decrease nociceptive …

As the largest family of ion channels, potassium (K+) channels have an extremely broad
distribution from viruses and bacteria to plants and animals (Korovkina and England 2002; …

Potassium (K+) channels play a critical role in regulating neuronal excitability, a
fundamental feature of pain. The opening of K+ channels leads to hyperpolarization of the …

Introduction CD4+ T cells express K 2P 5.1 (TWIK-related acid-sensitive potassium channel
2 (TASK2); KCNK5), a member of the two-pore domain potassium channel family, which has …