Macrophages are cells that function as a first line of defence against invading
microorganisms. One of the hallmarks of macrophages is their ability to become activated in …

Macrophages play key roles in inflammation. During the onset of the inflammatory process,
these phagocytic cells become activated and have destructive effects. Macrophage …

In this Viewpoint, we concentrate on the aspects of macrophage biology that we believe are
fundamental for an appropriate contextual understanding of macrophage function during …

Recent investigations have highlighted new roles for the macrophage (Mϕ) in the biology of
inflammation. Selective depletion of Mϕs from inflamed sites has confirmed their …

It used to be easy. In the old days (8 years ago), activated macrophages were simply defined
as cells that secreted inflammatory mediators and killed intracellular pathogens. Things are …

Macrophages make major contributions to inflammatory immunopathology. In this work, we
examine three disease scenarios, in which M1s play a major role early in the disease but …

Understanding the response of innate immune cells to pathogens may provide insights to
host defenses and the tactics used by pathogens to circumvent these defenses. We used …

Macrophages exhibit remarkable plasticity and can change their phenotype in response to
different environmental cues. They can become activated to kill intracellular microbes or they …

Macrophage activation, broadly defined as the acquisition of competence to execute a
complex function, continues to intrigue biologists, because of its fundamental importance to …

Macrophages display remarkable plasticity and can change their physiology in response to
environmental cues. These changes can give rise to different populations of cells with …