Hyperoside attenuates neuroinflammation, cognitive impairment and oxidative stress via suppressing TNF-α/NF-κB/caspase-3 signaling in type 2 diabetes rats

X Chen, AC Famurewa, J Tang… - Nutritional …, 2022 - Taylor & Francis
Objectives Literature findings have instituted the role of hyperglycemia-induced oxidative
stress and inflammation in the pathogenesis of cognitive derangement in diabetes mellitus …

Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt/β‐Catenin and Sonic Hedgehog Pathways

J Huang, L Zhou, J Chen, T Chen, B Lei… - Neural …, 2021 - Wiley Online Library
Neuroinflammation plays important roles in the pathogenesis and progression of altered
neurodevelopment, sensorineural hearing loss, and certain neurodegenerative diseases …

Hyperoside protects cortical neurons from oxygen–glucose deprivation–reperfusion induced injury via nitric oxide signal pathway

RL Liu, QJ Xiong, Q Shu, WN Wu, J Cheng, H Fu… - Brain research, 2012 - Elsevier
Hyperoside is a flavonoid compound and widely used in clinic to relieve pain and improve
cardiovascular functions. However, the effects of hyperoside on ischemic neurons and the …

Chrysophanol relieves cognition deficits and neuronal loss through inhibition of inflammation in diabetic mice

X Chu, S Zhou, R Sun, L Wang, C Xing, R Liang… - Neurochemical …, 2018 - Springer
Patients with diabetes mellitus are easy to experience diabetic encephalopathy (DE) and
other cognition dysfunction, whereas the neural alterations in developing this disease are …

[HTML][HTML] Attenuation of hyperglycemia-associated dyslipidemic, oxidative, cognitive, and inflammatory crises via modulation of neuronal ChEs/NF-κB/COX-2/NOx, and …

IA Hogan, YC Kuo, AN Abubakar, B Lawal… - Biomedicine & …, 2023 - Elsevier
Tridax procumbens (cotton buttons) is a flowering plant with a medicinal reputation for
treating infections, wounds, diabetes, and liver and kidney diseases. The present research …

Effect of docosahexaenoic acid on hippocampal neurons in high-glucose condition: involvement of PI3K/AKT/nuclear factor-κB-mediated inflammatory pathways

RH Yang, J Lin, XH Hou, R Cao, F Yu, HQ Liu, AL Ji… - Neuroscience, 2014 - Elsevier
Accumulating evidence suggested that hyperglycemia played a critical role in hippocampus
dysfunction in patients with diabetes mellitus. However, the multifactorial pathogenesis of …

Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway

Z Yin, H Yu, S Chen, C Ma, X Ma, L Xu, Z Ma… - Behavioural Brain …, 2015 - Elsevier
Diabetes-associated cognitive dysfunction, referred as “diabetic encephalopathy”, has been
confirmed in a great deal of literature. Current evidence support that oxidative stress …

Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

X Zhu, YM Zhang, MY Zhang, YJ Chen, YW Liu - Metabolic Brain Disease, 2021 - Springer
Diabetes-associated affective disorders are of wide concern, and oxidative stress plays a
vital role in the pathological process. This study was to investigate the cerebroprotective …

Carnosine ameliorates cognitive deficits in streptozotocin-induced diabetic rats: Possible involved mechanisms

S Ahshin-Majd, S Zamani, T Kiamari, Z Kiasalari… - Peptides, 2016 - Elsevier
Diabetic patients are at increased risk to develop cognitive deficit and senile dementia. This
study was planned to assess the benefits of chronic carnosine administration on prevention …

[HTML][HTML] Gastrodin ameliorates cognitive dysfunction in diabetes rat model via the suppression of endoplasmic reticulum stress and NLRP3 inflammasome activation

T Ye, X Meng, Y Zhai, W Xie, R Wang, G Sun… - Frontiers in …, 2018 - frontiersin.org
Patients with diabetes mellitus (DM) are at high risk for cognitive dysfunction. Endoplasmic
reticulum stress (ERS) and inflammation play crucial roles in DM. Gastrodin (Gas), the main …