[HTML][HTML] adeABC efflux gene in Acinetobacter baumannii

CF Xu, SR Bilya, W Xu - New microbes and new infections, 2019 - Elsevier
The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues
to grow; it has become a global health issue, particularly in regards to carbapenem …

The Asp20-to-Asn substitution in the response regulator AdeR leads to enhanced efflux activity of AdeB in Acinetobacter baumannii

J Nowak, T Schneiders, H Seifert… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Overexpression of the resistance-nodulation-cell division-type efflux pump AdeABC is often
associated with multidrug resistance in Acinetobacter baumannii and has been linked to …

Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii

IV Leus, J Adamiak, AN Trinh, RD Smith… - Molecular …, 2020 - Wiley Online Library
Multidrug resistant (MDR) strains of Acinetobacter baumannii present a serious clinical
challenge. The development of antibiotic resistance in this species is enabled by efflux …

Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter …

A Nemec, M Maixnerová… - Journal of …, 2007 - academic.oup.com
Objectives To assess the occurrence of the genes of the AdeABC efflux system and their
association with antimicrobial resistance in Acinetobacter baumannii. Methods A set of 116 …

Insertion sequence disruption of adeR and ciprofloxacin resistance caused by efflux pumps and gyrA and parC mutations in Acinetobacter baumannii

BS Lopes, SGB Amyes - International journal of antimicrobial agents, 2013 - Elsevier
Acinetobacter baumannii is a pathogenic bacterium responsible for a wide range of
infections in immunocompromised patients. This study examined the role of insertional …

AdeR-AdeS mutations & overexpression of the AdeABC efflux system in ciprofloxacin-resistant Acinetobacter baumannii clinical isolates

AR Lari, A Ardebili, A Hashemi - Indian Journal of Medical …, 2018 - journals.lww.com
Methods: Susceptibility of 50 clinical A. baumannii isolates to ciprofloxacin, imipenem,
ceftazidime, cefepime and gentamicin antimicrobials was evaluated by agar dilution method …

Distribution of the multidrug efflux pump genes, adeABC, adeDE and adeIJK, and class 1 integron genes in multiple-antimicrobial-resistant clinical isolates of …

L Lin, BD Ling, XZ Li - International journal of antimicrobial agents, 2009 - Elsevier
Of 112 non-repetitive clinical isolates of Acinetobacter baumannii–Acinetobacter
calcoaceticus complex, 80% were resistant to a variety of structurally unrelated …

A Truncated AdeS Kinase Protein Generated by ISAba1 Insertion Correlates with Tigecycline Resistance in Acinetobacter baumannii

JR Sun, CL Perng, MC Chan, Y Morita, JC Lin, CM Su… - PLoS …, 2012 - journals.plos.org
Over-expression of AdeABC efflux pump stimulated continuously by the mutated AdeRS two
component system has been found to result in antimicrobial resistance, even tigecycline …

RND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations

EJ Yoon, P Courvalin… - Antimicrobial agents and …, 2013 - Am Soc Microbiol
Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-
type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter …

[HTML][HTML] Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance

MF Lin, YY Lin, CC Tu, CY Lan - Journal of Microbiology, Immunology and …, 2017 - Elsevier
Background/purpose Efflux pumps are one of the major mechanisms of antimicrobial
resistance in Acinetobacter baumannii. This study aimed to understand the distribution of …