[HTML][HTML] A new platform for autoimmune diseases. Inducing tolerance with liposomes encapsulating autoantigens

L Almenara-Fuentes, S Rodriguez-Fernandez… - … , Biology and Medicine, 2023 - Elsevier
Autoimmune diseases (AIDs) are caused by the loss of self-tolerance and destruction of
tissues by the host's immune system. Several antigen-specific immunotherapies, focused on …

Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis

I Pujol-Autonell, MJ Mansilla… - …, 2017 - Future Medicine
Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were
generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our …

Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes

A Villalba, S Rodriguez-Fernandez… - Artificial Cells …, 2020 - Taylor & Francis
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of
insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we …

[HTML][HTML] Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes

I Garcia-Loza, D Perna-Barrull, E Aguilera… - Journal of …, 2024 - Elsevier
Abstract Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with
pivotal involvement of antigen-presenting cells. In this context, antigen-specific …

Time-controlled phagocytosis of asymmetric liposomes: Application to phosphatidylserine immunoliposomes binding HIV-1 virus-like particles

RA Petazzi, A Gramatica, A Herrmann… - … , Biology and Medicine, 2015 - Elsevier
Macrophage immune functions such as antibody-mediated phagocytosis are strongly
impaired in individuals affected by HIV-1. Nevertheless, infected macrophages are still able …

[HTML][HTML] Designing antigens for the prevention and treatment of autoimmune diseases

DC Wraith - Current opinion in chemical engineering, 2018 - Elsevier
Highlights•Dendritic cells can present antigen in either an immunogenic or tolerogenic
manner.•Liposomes and nanoparticles can deliver antigens to antigen presenting …

Multivalent Scaffolds to Promote B cell Tolerance

SN Johnson, SD Brucks, KD Apley… - Molecular …, 2023 - ACS Publications
Autoimmune diseases are characterized by aberrant immune responses toward self-
antigens. Current treatments lack specificity, promoting adverse effects by broadly …

Suppression of autoimmune rheumatoid arthritis with hybrid nanoparticles that induce B and T cell tolerance to self-antigen

KA Brzezicka, BM Arlian, S Wang, M Olmer, M Lotz… - ACS …, 2022 - ACS Publications
Autoimmune diseases affect over 4% of the world's population. Treatments are generally
palliative or use broad spectrum immunosuppressants to reduce symptoms and disease …

An insight into the role of liposomal therapeutics in the reversion of multiple sclerosis

N Rahiman, P Zamani, A Badiee, L Arabi… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction Multiple Sclerosis (MS), as an autoimmune disease, has
complicated immunopathology, which makes its management relevant to various factors …

αEnv-decorated phosphatidylserine liposomes trigger phagocytosis of HIV-virus-like particles in macrophages

A Gramatica, RA Petazzi, MJ Lehmann… - … , Biology and Medicine, 2014 - Elsevier
Macrophages represent an important cellular target of HIV-1. Interestingly, they are also
believed to play a potential role counteracting its infection. However, HIV-1 is known to …