Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications

S Ciafrè, G Ferraguti, A Greco, A Polimeni… - Neuroscience & …, 2020 - Elsevier
Ethanol exposure during gestation is an early life stressor that profoundly dysregulates
structure and functions of the embryonal nervous system, altering the cognitive and …

Molecular changes during neurodevelopment following second-trimester binge ethanol exposure in a mouse model of fetal alcohol spectrum disorder: from immediate …

K Mantha, BI Laufer, SM Singh - Developmental neuroscience, 2014 - karger.com
Fetal alcohol spectrum disorder (FASD) is an umbrella term that refers to a wide range of
behavioral and cognitive deficits resulting from prenatal alcohol exposure. It involves …

Aberrant behavioral and neurobiologic profiles in rodents exposed to ethanol or red wine early in development

S De Nicolò, V Carito, M Fiore, G Laviola - Current Developmental …, 2014 - Springer
Alcohol intake by women before planning a pregnancy, during pregnancy, and/or during
lactation induces brain, behavioral, and physical abnormalities in the fetus, which are known …

The role of oxidative stress in fetal alcohol spectrum disorders

PS Brocardo, J Gil-Mohapel, BR Christie - Brain research reviews, 2011 - Elsevier
The ingestion of alcohol/ethanol during pregnancy can result in abnormal fetal development
in both humans and a variety of experimental animal models. Depending on the pattern of …

Prenatal alcohol exposure: Foetal programming, the hypothalamic‐pituitary‐adrenal axis and sex differences in outcome

J Weinberg, JH Sliwowska, N Lan… - Journal of …, 2008 - Wiley Online Library
Prenatal exposure to alcohol has adverse effects on offspring neuroendocrine and
behavioural functions. Alcohol readily crosses the placenta, thus directly affecting …

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?

AA Lussier, J Weinberg, MS Kobor - Epigenomics, 2017 - Taylor & Francis
Adverse in utero events can alter the development and function of numerous physiological
systems, giving rise to lasting neurodevelopmental deficits. In particular, data have shown …

[HTML][HTML] The complex interplay of genetics, epigenetics, and environment in the predisposition to alcohol dependence

A Díaz-Anzaldúa, A Díaz-Martínez, LR Díaz-Martínez - Salud mental, 2011 - scielo.org.mx
Alcohol dependence is a major global problem, associated with lower quality of physical
and mental health, higher mortality and an enormous familial and social cost. Prevention …

Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders

ML Kleiber, EJ Diehl, BI Laufer, K Mantha… - Frontiers in …, 2014 - frontiersin.org
There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral
and cognitive impairments, categorized under the term fetal alcohol spectrum disorders …

Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure

E Comasco, J Rangmar, UJ Eriksson… - Acta …, 2018 - Wiley Online Library
Several explanations for the diverse results in research on foetal alcohol spectrum disorders
or alcohol‐related neurodevelopmental disorder might be at hand: timing, amount and …

Does moderate drinking harm the fetal brain? Insights from animal models

CF Valenzuela, RA Morton, MR Diaz, L Topper - Trends in neurosciences, 2012 - cell.com
Although public health campaigns advise pregnant women to abstain from ethanol, drinking
during pregnancy is pervasive. Here, we highlight recent studies that have clearly …