Breast cancer is both the most common type of cancer and the most frequent cause of
cancer mortality in women, mainly because of its heterogeneity and limited immunogenicity …

Next-generation sequencing technologies have provided insights into the biology and
mutational landscape of cancer. Here, we evaluate the relevance of cancer neoantigens in …

Breast cancer stands as a formidable global health challenge for women. While neoantigens
exhibit efficacy in activating T cells specific to cancer and instigating anti-tumor immune …

Simple Summary Neoantigens are novel proteins presented on the cell surface and derived
from the accumulation of somatic mutations in tumor cells. They can be recognized by the …

The immune system plays a dual role of host-protecting and tumor-promoting, as elegantly
expressed by the 'cancer immunoediting'hypothesis. Although breast cancer has not been …

Therapeutic cancer vaccines aim to treat pre-existing cancer by boosting the patient's own
immune system, which is an attractive strategy for cancer treatment. The cancer vaccines …

The search for target molecules on tumor cells eliciting strong immune responses in cancer
patients has been pursued over decades. Growth factors and their respective receptors were …

Introduction The discovery of neoantigens as mutated proteins specifically expressed in
tumor cells but not in normal cells has led to improved cancer vaccines. Targeting …

Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in
tumour cells. However, their effect on immune responses in the tumour microenvironment …

Somatic mutation-derived neoantigens, expressed only on tumor cells, may elicit antitumor T-
cell responses in cancer immunotherapies with minimal immune tolerance. Neoantigens …