Due to the limitations of bone autografts, we aimed to develop new composite biomaterials
with pro-angiogenic and osteogenic properties to be used as scaffolds in bone tissue …

There has been substantial progress made in the development of bone regeneration
materials, driven by the deficiencies that exist in current clinical products, such as finite …

Bone tissue engineering (BTE) aims to improve the healing of bone fractures using scaffolds
that mimic the native extracellular matrix. For successful bone regeneration, scaffolds should …

Vascularization of an artificial graft represents one of the most significant challenges facing
the field of bone tissue engineering. Over the past decade, strategies to vascularize artificial …

The fibrotic response of the body to synthetic polymers limits their success in tissue
engineering and other applications. Though porous polymers have demonstrated improved …

Cell-based tissue engineering is promising to create living functional tissues for bone
regeneration. The implanted cells should be evenly distributed in the scaffold, be fast …

Despite the recent advances in the development of bone graft substitutes, treatment of
critical size bone defects continues to be a significant challenge, especially in the elderly …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …

Tissue engineering (TE) represents a valid alternative to traditional surgical therapies for the
management of bone defects that do not regenerate spontaneously. Scaffolds, one of the …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …