The lung microbiome in moderate and severe chronic obstructive pulmonary disease

AA Pragman, HB Kim, CS Reilly, C Wendt… - 2012 - journals.plos.org
Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder characterized
by incompletely reversible airflow obstruction. Bacterial infection of the lower respiratory tract …

Host response to the lung microbiome in chronic obstructive pulmonary disease

MA Sze, PA Dimitriu, M Suzuki… - American journal of …, 2015 - atsjournals.org
Rationale: The relatively sparse but diverse microbiome in human lungs may become less
diverse in chronic obstructive pulmonary disease (COPD). This article examines the …

Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease

M Garcia-Nuñez, L Millares, X Pomares… - Journal of clinical …, 2014 - Am Soc Microbiol
Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often
demonstrated in chronic obstructive pulmonary disease (COPD), but culture-based …

COPD and the microbiome

MJ Mammen, S Sethi - Respirology, 2016 - Wiley Online Library
Traditional culture techniques confirm that bacteria have an important role in C hronic O
bstructive P ulmonary D isease (COPD). In individuals with COPD, acquisition of novel …

The lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease

AA Pragman, T Lyu, JA Baller, TJ Gould, RF Kelly… - Microbiome, 2018 - Springer
Background Oral taxa are often found in the chronic obstructive pulmonary disease (COPD)
lung microbiota, but it is not clear if this is due to a physiologic process such as aspiration or …

Microbiome diversity in the bronchial tracts of patients with chronic obstructive pulmonary disease

R Cabrera-Rubio, M Garcia-Núñez, L Setó… - Journal of clinical …, 2012 - Am Soc Microbiol
Culture of bacteria from bronchial secretions in respiratory patients has low sensitivity and
does not allow for complete assessment of microbial diversity across different bronchial …

Lung microbiome dynamics in COPD exacerbations

Z Wang, M Bafadhel, K Haldar, A Spivak… - European …, 2016 - Eur Respiratory Soc
Increasing evidence suggests that the lung microbiome plays an important role in chronic
obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung …

Analysis of the lung microbiome in the “healthy” smoker and in COPD

JR Erb-Downward, DL Thompson, MK Han… - PloS one, 2011 - journals.plos.org
Although culture-independent techniques have shown that the lungs are not sterile, little is
known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We …

The lung tissue microbiome in chronic obstructive pulmonary disease

MA Sze, PA Dimitriu, S Hayashi, WM Elliott… - American journal of …, 2012 - atsjournals.org
Rationale: Based on surface brushings and bronchoalveolar lavage fluid, Hilty and
coworkers demonstrated microbiomes in the human lung characteristic of asthma and …

Bacterial microbiome of lungs in COPD

MA Sze, JC Hogg, DD Sin - International journal of chronic …, 2014 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death
in the world. Although smoking is the main risk factor for this disease, only a minority of …