The alveolar region of the lung creates an extensive epithelial surface that mediates the
transfer of oxygen and carbon dioxide required for respiration after birth. Maintenance of …

Advances in physiology and biochemistry have provided fundamental insights into the role
of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory …

Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation
of surfactant in alveolar macrophages and alveoli resulting in hypoxemic respiratory failure …

Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

Surfactant is an agent that decreases the surface tension between two media. The surface
tension between gaseous-aqueous interphase in the lungs is decreased by the presence of …

The first successful clinical pilot studies of surfactant replacement were published about 20
years ago as a logical extension of experimental studies showing beneficial effects in pre …

Gas exchange after birth is entirely dependent on the remarkable architecture of the
alveolus, its formation and function being mediated by the interactions of numerous cell …

Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units
(alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant …

Pulmonary surfactant is synthesized and secreted by alveolar type II cells and constitutes an
important component of the alveolar lining fluid. It comprises a unique mixture of …

Pulmonary surfactant is a crucial and dynamic lung structure whose primary functions are to
reduce alveolar surface tension and facilitate breathing. Though disruptions in surfactant …