Background: The blood level of tacrolimus (TAC) used for post-transplant
immunosuppression should be within the therapeutic index. Geriatric individuals may be at …

Tacrolimus (TAC) has a narrow therapeutic index and highly variable pharmacokinetic
characteristics. Close monitoring of the TAC concentrations is required in order to avoid the …

Relaxation of the upper age limits for solid organ transplantation coupled with improvements
in post-transplant survival have resulted in greater numbers of elderly patients receiving …

BACKGROUND: Tacrolimus is a macrolide immunosuppressant indicated for prophylaxis of
transplant rejection. The European regulatory authorities require comparative bioavailability …

BACKGROUND: Most previous studies having focused on therapeutic drug monitoring of
tacrolimus in renal transplant recipients have assessed the clinical response of patients. The …

Background The possible influence of gender on tacrolimus disposition and response in
kidney transplant recipients is an issue of medical importance. Objective The aim of this …

Objectives Despite the intensive therapeutic drug monitoring of tacrolimus (TAC) using
trough whole blood concentrations, graft rejections occur in transplant recipient patients …

Background and Importance Tacrolimus (TAC) is the first-choice immunosuppressant for
patients undergoing kidney transplantation. However, it has considerable drug interactions …

Background: Use of tacrolimus (Tac) is pivotal to renal transplant (RT) immunosuppressive
maintenance regiments. The most frequently used means of Tac monitoring is the …

We determined the trough blood and plasma concentrations of tacrolimus from the day of
transplantation through 30 days posttransplantation in four liver and four kidney transplant …