Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases
MK Sobczyk, J Zheng, GD Smith, TR Gaunt - BMJ open, 2023 - bmjopen.bmj.com
Objective To scope the potential for (semi)-automated triangulation of Mendelian
randomisation (MR) and randomised controlled trials (RCTs) evidence since the two …
randomisation (MR) and randomised controlled trials (RCTs) evidence since the two …
Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review
Abstract Background The use of Mendelian randomization (MR) in epidemiology has
increased considerably in recent years, with a subsequent increase in systematic reviews of …
increased considerably in recent years, with a subsequent increase in systematic reviews of …
How to interpret studies using Mendelian randomisation
The importance of causal inference in biomedical science cannot be overstated. It can help
determine the direction of effect, the mechanisms behind observed associations and …
determine the direction of effect, the mechanisms behind observed associations and …
Nature as a trialist?: deconstructing the analogy between Mendelian randomization and randomized trials
Mendelian randomization (MR) studies are often described as naturally occurring
randomized trials in which genetic factors are randomly assigned by nature …
randomized trials in which genetic factors are randomly assigned by nature …
Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative …
Background Mendelian randomization (MR) is fast becoming a popular method to judge
causality from routinely conducted observational studies. However, stringent underlying …
causality from routinely conducted observational studies. However, stringent underlying …
A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization studies
Mendelian randomization (MR) has been increasingly used to interrogate the causal effects
of modifiable risk factors on human health and disease over the last 15 years. As MR …
of modifiable risk factors on human health and disease over the last 15 years. As MR …
Using Mendelian randomization to assess and develop clinical interventions: limitations and benefits
S Burgess, A Malarstig - Journal of Comparative …, 2013 - becarispublishing.com
It is a truth universally acknowledged that in order to popularize a new epidemiological
technique, one has to invent a suitably exciting sounding name for it. The term 'Mendelian …
technique, one has to invent a suitably exciting sounding name for it. The term 'Mendelian …
A systematic literature review of methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology
Background Diseases diagnosed in adulthood may have antecedents throughout–including
prenatal–life. Gaining a better understanding of how exposures at different stages in the …
prenatal–life. Gaining a better understanding of how exposures at different stages in the …
Recent developments in Mendelian randomization studies
Abstract Purpose of Review Mendelian randomization (MR) is a strategy for evaluating
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
Reporting and methodological quality of studies that use Mendelian randomisation in UK Biobank: a meta-epidemiological study
Objectives To identify whether Mendelian randomisation (MR) studies are appropriately
conducted and reported in enough detail for other researchers to accurately replicate and …
conducted and reported in enough detail for other researchers to accurately replicate and …