Lyso-thermosensitive liposomal doxorubicin: an adjuvant to increase the cure rate of radiofrequency ablation in liver cancer
RTP Poon, N Borys - Future Oncology, 2011 - Taylor & Francis
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. No
more than 30% of HCC patients are considered suitable for curative treatment because of …
more than 30% of HCC patients are considered suitable for curative treatment because of …
Phase III HEAT study adding lyso-thermosensitive liposomal doxorubicin to radiofrequency ablation in patients with unresectable hepatocellular carcinoma lesions
WY Tak, SM Lin, Y Wang, J Zheng, A Vecchione… - Clinical Cancer …, 2018 - AACR
Purpose: Lyso-thermosensitive liposomal doxorubicin (LTLD) consists of doxorubicin
contained within a heat-sensitive liposome. When heated to≥ 40° C, LTLD locally releases …
contained within a heat-sensitive liposome. When heated to≥ 40° C, LTLD locally releases …
Lyso-thermosensitive liposomal doxorubicin: a novel approach to enhance efficacy of thermal ablation of liver cancer
RTP Poon, N Borys - Expert opinion on pharmacotherapy, 2009 - Taylor & Francis
Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death
worldwide. No more than 30% of HCC patients receive curative treatment. Factors limiting …
worldwide. No more than 30% of HCC patients receive curative treatment. Factors limiting …
RFA plus lyso-thermosensitive liposomal doxorubicin: in search of the optimal approach to cure intermediate-size hepatocellular carcinoma
R Lencioni, D Cioni - Hepatic oncology, 2016 - Taylor & Francis
When heated during a radiofrequency ablation (RFA) procedure to≥ 40° C, lyso-
thermosensitive liposomal doxorubicin (LTLD) produces high drug concentration in the …
thermosensitive liposomal doxorubicin (LTLD) produces high drug concentration in the …
[HTML][HTML] Thermosensitive liposomal doxorubicin plus radiofrequency ablation increased tumor destruction and improved survival in patients with medium and large …
W Yang, JC Lee, MH Chen, ZY Zhang… - Journal of Cancer …, 2019 - journals.lww.com
Background: Lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox) consists of
doxorubicin encapsulated contained within a heat-sensitive liposome. Aims and Objectives …
doxorubicin encapsulated contained within a heat-sensitive liposome. Aims and Objectives …
Phase I study of heat-deployed liposomal doxorubicin during radiofrequency ablation for hepatic malignancies
BJ Wood, RT Poon, JK Locklin, MR Dreher… - Journal of Vascular and …, 2012 - Elsevier
PURPOSE: A phase I dose escalation study was performed with systemically delivered lyso-
thermosensitive liposomal doxorubicin (LTLD). The primary objectives were to determine the …
thermosensitive liposomal doxorubicin (LTLD). The primary objectives were to determine the …
[HTML][HTML] Increased duration of heating boosts local drug deposition during radiofrequency ablation in combination with thermally sensitive liposomes (ThermoDox) in a …
CE Swenson, D Haemmerich, DH Maul, B Knox… - PloS one, 2015 - journals.plos.org
Introduction Radiofrequency ablation (RFA) is used for the local treatment of liver cancer.
RFA is effective for small (< 3cm) tumors, but for tumors> 3 cm, there is a tendency to leave …
RFA is effective for small (< 3cm) tumors, but for tumors> 3 cm, there is a tendency to leave …
[HTML][HTML] Therapeutic efficacy of combining pegylated liposomal doxorubicin and radiofrequency (RF) ablation: comparison between slow-drug-releasing, non …
AV Andriyanov, E Koren, Y Barenholz, SN Goldberg - PloS one, 2014 - journals.plos.org
Aims To determine how the accumulation of drug in mice bearing an extra-hepatic tumor
and its therapeutic efficacy are affected by the type of PEGylated liposomal doxorubicin …
and its therapeutic efficacy are affected by the type of PEGylated liposomal doxorubicin …
Combination radiofrequency thermal ablation and adjuvant IV liposomal doxorubicin increases tissue coagulation and intratumoural drug accumulation
M Ahmed, SN Goldberg - International journal of hyperthermia, 2004 - Taylor & Francis
There has been marked interest in minimally-invasive, image-guided radiofrequency (RF)
tumour ablation (ie coagulating tumour using short duration heating (< 15 min) by directly …
tumour ablation (ie coagulating tumour using short duration heating (< 15 min) by directly …
Tumor-penetrating peptide-integrated thermally sensitive liposomal doxorubicin enhances efficacy of radiofrequency ablation in liver tumors
F Yan, S Wang, W Yang, SN Goldberg, H Wu, WL Duan… - Radiology, 2017 - pubs.rsna.org
Purpose To investigate the role of a tumor-penetrating peptide (internalizing CRGDRGPDC
[iRGD])–integrated thermally sensitive liposomal (TSL) doxorubicin (DOX) in combination …
[iRGD])–integrated thermally sensitive liposomal (TSL) doxorubicin (DOX) in combination …
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