Despite intense research efforts and major advances in the understanding of particular
aspects of the disease process, the etiology of SSc is still unknown and the pathogenesis …

Systemic sclerosis (SSc) belongs to the group of “diffuse inflammatory connective tissue
diseases” or “collagen vascular diseases” comprising a variety of severe, sometimes life …

Systemic sclerosis (SSc) is a heterogenous disease with a morbidity and mortality that varies
widely. Nonetheless, the future clinical course of an individual patient can be estimated …

Systemic sclerosis (SSc, scleroderma) is a disease characterized by fibrosis of the skin and
internal organs due to increased synthesis and deposition of extracellular matrix. The …

Systemic sclerosis (SSc, also called scleroderma) is an autoimmune connective tissue
disease characterized by cutaneous sclerosis. It commonly progresses to involve fibrosis of …

Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by three
cardinal pathogenic features: autoimmunity, vasculopathy, and fibrosis. The prevalence of …

Publisher Summary Systemic scleroderma (SSc) is a chronic progressive disease, which
manifests clinically by the sequential appearance of three phases of skin changes: an initial …

Systemic scleroderma is a generalized disease of connective tissue involving mainly the
skin, the gastrointestinal tract, the lungs, the heart, and the kidneys. It can be present in …

Systemic sclerosis (SSc), also called scleroderma, is a progressive multisystem disease
characterized by autoimmunity, endothelial cell dysfunction, and excessive fibrosis. In …

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by
severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the …