Oxidative stress is the leading cause of most liver diseases, such as drug-induced liver
injury, viral hepatitis, and alcoholic hepatitis caused by drugs, viruses, and ethanol. The …

Abstract Nuclear erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidative
response elements-mediated gene expression. It has a significant role in adaptive …

Oxidative stress and inflammation are the most important pathogenic events in the
development and progression of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) is …

Liver diseases represent a critical health problem with 2 million deaths worldwide per year,
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …

The liver is a central organ that performs a wide range of functions such as detoxification
and metabolic homeostasis. Since it is a metabolically active organ, liver is particularly …

In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription
factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been …

Oxidative stress–mediated destruction of normal parenchymal cells during hepatic
inflammatory responses contributes to the pathogenesis of immune-mediated hepatitis and …

Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

Background & Aims In chronic liver diseases, inflammation induces oxidative stress and thus
may contribute to the progression of liver injury, fibrosis, and carcinogenesis. The …