Simple Summary Metastasis formation and dissemination is a complex process that relies
on several steps. Even though highly inefficient, metastasis spreading is the primary cause …

Dock4 is a member of the Dock180 family of proteins that mediates cancer cell migration
through activation of Rac. However, the regulatory mechanism of Dock4 remains unclear. In …

The Rho family of small GTPases is known to be important for the regulation of cell motility. A
recent paper by Chris Marshall and colleagues published in Cell has shown that differential …

ShcD was previously found to promote cell motility in melanoma cells. Screening of a yeast
two hybrid mouse embryo cDNA library identified Nischarin, a negative regulator to cell …

Neural precursor expressed, developmentally down-regulated 9 (NEDD9), a member of the
Cas family of signal transduction molecules, is amplified at the genetic level in melanoma …

Simple Summary Melanoma is a growing health issue in the 21st century. Due to early
metastasis and the development of resistance, it still goes along with a poor prognosis …

Aims Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most dismal
malignancies worldwide. Despite multidisciplinary involvement in interventions involving …

DOCK2; a member of the CDM protein family, regulates cell motility and cytokine production
through the activation of Rac in mammalian hematopoietic cells and plays a pivotal role in …

Tumour cells alter their gene expression profile to acquire a more invasive and resistant
phenotype. Overexpression of the signalling adaptor protein ShcD in melanoma was found …

Progression of solid tumors to the metastatic stage is accountable for the majority of cancer-
related deaths. Further understanding of the molecular mechanisms governing metastasis is …