Background & Aims Studies have demonstrated that activated pancreatic stellate cells
(PSCs) play a crucial role in pancreatic fibrogenesis in chronic pancreatitis (CP); however …

Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that governs various
functions by embedding its receptor, S1PR, in different cells. Chronic pancreatitis (CP) is …

Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that
accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is …

In the complex progression of fibrosis in chronic pancreatitis, pancreatic stellate cells (PSCs)
emerge as central figures. These cells, initially in a dormant state characterized by the …

As a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various
pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the …

Over a decade, there is accumulating evidence that activated pancreatic stellate cells
(PSCs) play a pivotal role in the development of pancreatic fibrosis. In response to …

Chronic pancreatitis (CP) is a precancerous illness linked to pancreatic ductal
adenocarcinoma (PDAC), although the evolutionary mechanism is uncertain. CP is …

Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and
pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the …

Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

Significance: Prominent fibrosis is a major histological feature of chronic pancreatitis, a
progressive necroinflammatory condition of the pancreas, most commonly associated with …