While estrogen receptor (ER)-targeted therapeutics have clearly been a success in the
treatment of breast cancer, the orphan estrogen-related receptors (ERRs) represent novel …

The identification of two genes encoding polypeptides with structural features common with
the estrogen receptor more than a quarter century ago, referred to as the estrogen-related …

Estrogen receptors (ERs) are proteins that mediate the action of estradiol and a series of
natural and synthetic chemicals that mimic the estradiol structure. Estrogenic action was …

Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …

Most of the biological effects of estrogens are mediated via the estrogen receptors (ERs) at
the level of gene regulation. Recently, new information regarding the role of ERs in …

Central Nervous System and the Hypothalamo-Pituitary Axis: Estrogens are reported to
influence a variety of functions in the central nervous system (CNS) such as learning …

The estrogen receptor α (ERα) has proven to be the single most important target in breast
cancer over the last 30 years. The use of the selective ER modulator (SERM) tamoxifen for …

Over the past two decades, we have learned that estrogens play important physiological
roles not only in women but also in men and that the biological effects of estrogen are …

The nuclear receptor family comprises ligand-dependent and orphan receptors. To the latter
group belong the estrogen receptor-related receptors (ERRs) for which conflicting results …

Today we have to consider the existence of two estrogen receptors, a and b, in our attempts
to understand the role of estrogen receptors in physiology and pathology, and to explain the …