Retinal organoids from human-induced pluripotent stem cells: From studying retinal dystrophies to early diagnosis of Alzheimer's and Parkinson's disease

MI Móvio, TH de Lima-Vasconcellos… - Seminars in Cell & …, 2023 - Elsevier
Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …

Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish

XH Zhang, ZB Jin - 2021 - digitum.um.es
Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the
capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal …

Differentiation of retinal organoids from human pluripotent stem cells

CM Fligor, KC Huang, SS Lavekar, KB VanderWall… - Methods in Cell …, 2020 - Elsevier
Human pluripotent stem cells (hPSCs) possess the remarkable ability to differentiate into
any cell type of the body, including those of the retina. Through the differentiation of these …

Retinal and Brain Organoids: Bridging the Gap Between in vivo Physiology and in vitro Micro-Physiology for the Study of Alzheimer's Diseases

C Brighi, F Cordella, L Chiriatti, A Soloperto… - Frontiers in …, 2020 - frontiersin.org
Recent progress in tissue engineering has led to increasingly complex approaches to
investigate human neurodegenerative diseases in vitro, such as Alzheimer's disease …

Modeling retinal dystrophies using patient-derived induced pluripotent stem cells

KJ Wahlin, J Maruotti, DJ Zack - Retinal Degenerative Diseases …, 2014 - Springer
Retinal degenerative disease involving photoreceptor (PR) cell loss results in permanent
vision loss and often blindness. Generation of induced pluripotent stem cell (iPSC)-derived …

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Y Liang, X Sun, C Duan, S Tang, J Chen - Stem Cell Research & Therapy, 2023 - Springer
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration
and impose a considerable economic burden on patients and society, making efforts to cure …

[HTML][HTML] Strategies for retinal cell generation from human pluripotent stem cells

LS Weed, JA Mills - Stem Cell Investigation, 2017 - ncbi.nlm.nih.gov
Induced pluripotent stem cells (iPSCs) are specialized self-renewing cells that are
generated by exogenously expressing pluripotency-associated transcription factors in …

Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies

K Kruczek, A Swaroop - Stem Cells, 2020 - academic.oup.com
Retinal diseases constitute a genetically and phenotypically diverse group of clinical
conditions leading to vision impairment or blindness with limited treatment options …

Directed induction of retinal organoids from human pluripotent stem cells

X Zhang, ZB Jin - JoVE (Journal of Visualized Experiments), 2021 - jove.com
Retinal cell transplantation is a promising therapeutic approach, which could restore the
retinal architecture and stabilize or even improve the visual capabilities to the degenerated …

Differentiation of retinal organoids from human pluripotent stem cells

V Chichagova, B Dorgau, M Felemban… - Current Protocols in …, 2019 - Wiley Online Library
This unit describes a protocol for generating retinal organoids that contain all major retinal
cell types and are responsive to light from human pluripotent stem cells (hPSCs). hPSCs are …