Prothrombin Complex Concentrate to Treat Coagulation Disturbances in Pediatric Patients With Intracranial Pathology Including Traumatic Brain Injury

C Reeves, EA Sribnick, JD Tobias - International Journal of Clinical …, 2024 - theijcp.org
Background: Coagulation disturbances and hemorrhage are common in critically ill pediatric
patients especially those with intracranial pathology or traumatic brain injury (TBI). Even with …

Single-center use of prothrombin complex concentrate in pediatric patients

T Karube, C Andersen, JD Tobias - Journal of Pediatric …, 2020 - thieme-connect.com
Coagulation disturbances frequently occur in critically ill children. Four-factor prothrombin
complex concentrate (4F-PCC) may have a potential role in managing these patients while …

Effectiveness and safety of 4-factor prothrombin complex concentrate (4PCC) in neonates with intractable bleeding or severe coagulation disturbances: a retrospective …

G Mitsiakos, M Karametou, A Gkampeta… - Journal of Pediatric …, 2019 - journals.lww.com
Background: To date, clinical experience with prothrombin complex concentrate (PCC) in
the neonatal population has been limited. Aim: The objective of this study was to describe …

Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis

L Zeng, I Choonara, L Zhang, Y Li, J Shi - European journal of pediatrics, 2017 - Springer
To systematically evaluate the effectiveness of prothrombin complex concentrate (PCC) in
neonates and infants, we performed a systematic review and meta-analysis based on …

Prothrombin Complex Concentrate Utilization in Children's Hospitals

JE Lutmer, C Mpody, EA Sribnick… - Journal of Pediatric …, 2023 - thieme-connect.com
Prothrombin complex concentrates (PCCs) are used to manage bleeding in critically ill
children. We performed a repeat cross-sectional study using the Pediatric Health Information …

Pre hospital administration of prothrombin complex concentrate in the head injured patient, a service evaluation

RA Lendrum, JP Kotze, AE Weaver - Scandinavian Journal of Trauma …, 2013 - Springer
Pre hospital administration of prothrombin complex concentrate in the head injured patient,
a service evaluation Page 1 MEETING ABSTRACT Open Access Pre hospital …

[HTML][HTML] The Off-Label Use of Four-Factor Prothrombin Complex Concentrate: A Single Institution Retrospective Study

CD Scharman, E Kim, JJ Shatzel, TG Deloughery - Blood, 2017 - Elsevier
Abstract Background/Introduction: 4-factor prothrombin complex concentrate (PCC) is
currently approved in the United States for the urgent reversal of warfarin-induced …

Prothrombin complex concentrate: an effective therapy in reversing the coagulopathy of traumatic brain injury

B Joseph, P Hadjizacharia, H Aziz… - Journal of Trauma …, 2013 - journals.lww.com
BACKGROUND Coagulopathy in patients with traumatic brain injury (TBI) is a well-studied
concept. Prothrombin complex concentrate (PCC) has been shown to be an effective …

Correction to: Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta …

L Zeng, I Choonara, L Zhang, Y Li… - European Journal of …, 2023 - search.proquest.com
The Fig. 1 in the original version of the above article contained errors. The number of" Full-
text articles excluded, with reasons" should have been 181 rather than 180 and as the …

The clinical use of prothrombin complex concentrate

J Ferreira, M DeLosSantos - The Journal of emergency medicine, 2013 - Elsevier
BACKGROUND: Prothrombin complex concentrate (PCC) is an inactivated concentrate of
factors II, IX, and X, with variable amounts of factor VII. Guidelines recommend the use of …