Third-line therapy for chronic myeloid leukemia: current status and future directions

J Cortes, F Lang - Journal of Hematology & Oncology, 2021 - Springer
Chronic myeloid leukemia (CML) is driven by the BCR-ABL1 fusion protein, formed by a
translocation between chromosomes 9 and 22 that creates the Philadelphia chromosome …

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Chronic Myeloid Leukemia (CML) is a myeloproliferative
neoplasm with an incidence of 1–2 cases per 100 000 adults. It accounts for approximately …

Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions

AEG Osman, MW Deininger - Blood reviews, 2021 - Elsevier
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by a reciprocal
translocation [t (9; 22)(q34; q11. 2)] that leads to the fusion of ABL1 gene sequences (9q34) …

Chronic myeloid leukemia: 2016 update on diagnosis, therapy, and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2016 - Wiley Online Library
Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with
an incidence of 1‐2 cases per 100,000 adults. It accounts for approximately 15% of newly …

Mechanisms of resistance to ABL kinase inhibition in chronic myeloid leukemia and the development of next generation ABL kinase inhibitors

AB Patel, T O'Hare… - Hematology/Oncology …, 2017 - hemonc.theclinics.com
Every year, more than 8000 new cases of chronic myeloid leukemia (CML) are diagnosed in
the United States. 1 BCR-ABL1, a fusion protein kinase derived from a reciprocal …

Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2018 - Wiley Online Library
Disease overview Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an
incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly …

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring

E Jabbour, H Kantarjian - American journal of hematology, 2020 - Wiley Online Library
Disease overview Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an
incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly …

Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management

E Jabbour, H Kantarjian - American journal of hematology, 2014 - Wiley Online Library
Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with
an incidence of 1–2 cases per 100,000 adults, and accounts for∼ 15% of newly diagnosed …

Chronic myeloid leukemia: 2012 update on diagnosis, monitoring, and management

E Jabbour, H Kantarjian - American journal of hematology, 2012 - Wiley Online Library
Abstract Disease overview: Chronic Myeloid Leukemia (CML) is a myeloproliferative
neoplasm with an incidence of one–two cases per 100,000 adults and accounts for∼ 15 …

Chronic myelogenous leukemia

H Kantarjian, E Jabbour, S O'Brien - Molecular Hematology, 2024 - Wiley Online Library
This chapter summarizes our knowledge regarding the molecular biology of chronic myeloid
leukemia (CML) and its treatment modalities using the breakpoint cluster region‐v‐abl …