Although anti-retroviral therapy (ART) is highly effective in suppressing HIV replication, it
fails to eradicate the virus from HIV-infected individuals. Stable latent HIV reservoirs are …

Objective: Although HAART effectively suppresses viral replication, it fails to eradicate latent
viral reservoirs. The 'shock and kill'strategy involves the activation of HIV from latent …

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional
silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi …

None of the currently used anti-HIV-1 agents can effectively eliminate latent HIV-1
reservoirs, which is a major hurdle to a complete cure for AIDS. We report here that a novel …

The persistence of latently infected cells in patients under combinatory antiretroviral therapy
(cART) is a major hurdle to HIV-1 eradication. Strategies to purge these reservoirs are …

Highly active antiretroviral therapy (HAART) is very effective in suppressing HIV-1 replication
and restoring immune functions in HIV-infected individuals. However, it fails to eradicate the …

Persistent latent reservoir in resting CD4+ T cells is a major obstacle in curing HIV-1
infection. Effective strategies for eradication of the HIV-1 reservoir are urgently needed. We …

The human immunodeficiency virus type 1 (HIV-1) latent reservoir in resting CD4+ T cells
represents a major barrier to viral eradication. Small compounds capable of latency reversal …

Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The 'shock
and kill'strategy has been broadly explored to purge the latent reservoir; however, none of …

Abstract Background Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life
span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs …