Fourteen quinolizidine derivatives, structurally related to the alkaloids lupinine and cytisine
and previously studied for other pharmacological purposes, were presently tested for …

Fifteen quinolizidine derivatives have been tested for antiarrhythmic, inotropic, and
chronotropic effects on isolated guinea pig (gp) heart tissues and to assess calcium …

Eighteen analogues of lidocaine, mexiletine, and procainamide were synthesized, replacing
their aminoalkyl chains with the rigid and cumbersome quinolizidine nucleus. The target …

Chloroform inhalation leading rapidly to respiratory arrest produced ventricular fibrillation.
Pretreatment with quinidine prevented the development of the arrhythmia and provided the …

A series of diastereoisomeric 6-benzoyloxy-and 6-benzamido-2-
methyldecahydroisoquinolines has beenprepared and screened forantiarrhythmic …

Among 15 novel decahydroquinoline derivatives (D1–15), four of them displayed
antiarrhythmic activity (D12–D15). D12–D15 compounds were more active in the model of …

The antiarrhythmic and electrophysiological actions of quinacainol, a new Class I
antiarrhythmic, were assessed in rats. Electrophysiological actions of quinacainol were …

Earlier we synthesized 4-spiro-substituted tetrahydroisoquinolines (THI) containing phenyl
and benzyl groups with methoxyl substituents in the 1 position [1–3]; we studied their effect …

A number of the title compounds (1) and a few related hydroquinone derivatives (2) have
been synthesized and tested for antiarrhythmic activity in vivo (protectionagainst CaCl2 …

A series of 6-(3-amino-2-hydroxypropoxy)-2 (LH)-quinolinones has been synthesized and
evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a …