Aim Although cognitive deficits commonly co‐occur with stress‐related emotional disorders,
effect of procognitive drugs such as histaminergic H3 receptor antagonists are scarcely …

Rationale The role of histamine neurons in stress evoked cognitive impairments remains
unclear. Previous research has indicated that the blockade of H (3)-type histamine receptors …

Despite the development of neuroscience and spectacular discoveries, the clear functions
and the role of histamine are still not fully understood, especially in the context of the …

Numerous studies have demonstrated that brain histamine plays a crucial role in learning
and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been …

The neural histaminergic system modulates cognitive performance in various animal
models. However, little is known about the effects of the H4 histaminergic receptor in the …

Retrieval represents a dynamic process that may require neuromodulatory signaling. Here,
we report that the integrity of the brain histaminergic system is necessary for retrieval of …

The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R
antagonists in pharmacological control of neurodegenerative disorders, eg, Alzheimer …

Background: Histamine is a modulatory neurotransmitter regulating neuronal activity.
Antidepressant drugs target modulatory neurotransmitters, thus ultimately regulating …

Background: A considerable number of competitive antagonists/inverse agonists of
histamine H3 receptor (H3R) have progressed to clinical assessment, with pitolisant …

Background Alzheimer disease (AD) is the main cause of dementia in elderly people. The
potential of histamine H3 receptor (H3R) antagonists as a pharmacological treatment of …