Young adult obese fa/fa Zucker rats are hyperinsulinémie, hyperlipidémie and insulin
resistant. Pancreatic islets of fa/fa rats exhibit increased glucose sensitivity (half maximal …

Young aduît obese falfa Zucker rats are hyperinsulinemic. hyperlipidemic and insu lin
resistant. Pancreatic Mets of fatfa rats exhibit increased glucose sensitivity (half maximal …

Adrenalectomy prevents development of obesity and hyperinsulinaemia in obese (fa/fa)
Zucker rats, thereby implicating the hypothalamopituitary-adrenal axis in the pathogenesis of …

The objectives of this study were to document the effects of moderate aerobic exercise on
insulin secretion and other metabolic indices in fa/fa rats and to determine if a high-fat (HF) …

Our previous studies showed that dexamethasone treatment and high fat diets increased
pancreatic [beta]-cell mass as well as insulin resistance. By contrast, exercise increased …

Although exercise has been proposed to be beneficial to type 2 diabetes, its effects on β-cell
function and mass remain unclear. In the present study, the effects of long-term swimming …

Background/Aims: Metabolic syndrome has been identified as one of the most significant
threats to human health in the 21 st century. Exercise training has been shown to counteract …

Physical activity improves glycemic control in type 2 diabetes (T2DM) patients. However,
several human studies reported either no improvement or a lowering of insulin secretion …

The aim of this study was to examine the effect of insulin resistance on B-cell function and
replication. To this end insulin-resistant spontaneously hypertensive rats (SHR) and age …

Objective In normal B-cells, glucokinase activity is regulated by glucose. We hypothesized
that chronic exposure to low or high glucose levels would regulate glucokinase function and …