System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording …

LS Powers, JV Fairbanks, JM Roveda - US Patent 9,867,250, 2018 - Google Patents
A high intensity, ultra-short LED pulsing driver circuit is developed for use with a system
designed to perform real-time time-resolved, transient recording of a fluorescence. Details of …

High power, sinusoidal LED driver with temperature stabilization feedback and photomultiplier system

LS Powers, JV Fairbanks, JM Roveda - US Patent 10,021,747, 2018 - Google Patents
A high intensity, ultra-short LED pulsing driver circuit is developed for use with a system
designed to perform real-time time-resolved, transient recording of fluorescence. Details of …

Large dynamic range light detection

KL Staton, AN Dorsel, A Schleifer - US Patent 6,518,556, 2003 - Google Patents
This invention relates to large dynamic range light detec tion and more particularly to a
System for use in fluorescence readers to accommodate large dynamic ranges while main …

Phase-modulation fluorometer and method for measuring nanosecond lifetimes using a lock-in amplifier

G Rao, P Harms - US Patent 6,426,505, 2002 - Google Patents
A low cost apparatus and method for measuring nanosecond luminescence lifetimes with a
modulated LED light source that is driven by a lock-in amplifier. The lock-in amplifier …

Fluorescence detection with increased dynamic range

JF Corson - US Patent 6,806,460, 2004 - Google Patents
In one aspect, the light detection System of the invention includes at least two light detection
elements with each element responsive to a Selected light color in a first mode. In a Second …

Fluorescent-particle analyzer with timing alignment for analog pulse subtraction of fluorescent pulses arising from different excitation locations

MA Hoffman - US Patent 5,682,038, 1997 - Google Patents
Aflow cytometry system includes a flow tube through which particles marked with different
fluorochromes pass from a first location, illuminated by a red laser, to a second location …

Method and appartatus for improved time-resolved fluorescence spectroscopy

YS Chao, SM Fernandez, EF Guignon - US Patent 4,855,930, 1989 - Google Patents
A method and apparatus for time-resolved fluorescence spectroscopy is described in which
laser light from a single pulse is used to excite fluorescent photons in a sample, which …

Pulsed-multiline excitation for color-blind fluorescence detection

GBI Scott, C Kittrell, RF Curl, ML Metzker - US Patent 8,089,628, 2012 - Google Patents
US8089628B2 - Pulsed-multiline excitation for color-blind fluorescence detection - Google
Patents US8089628B2 - Pulsed-multiline excitation for color-blind fluorescence detection …

Exponential decay time constant measurement using frequency of offset phase-locked loop: system and method

JN Dukes, WF Carlsen Jr, RJ Pittaro - US Patent 4,716,363, 1987 - Google Patents
Oxygen determination based on luminescence quenching of fluorescent dye is effected by
using the frequency output of an offset-phase locked loop to calculate the time constant for …

Sensors for detection and spectroscopy

BS Carlson, M Gouzman, V Gorfinkel, S Luryi - US Patent 6,038,023, 2000 - Google Patents
For multicolor fluorescence detection or spectroscopy with low signal-to-noise ratio and
rapid readout, signals from multiple sensors are combined in analog form so that only one …