Alzheimer's disease (AD) is the most frequent cause of dementia. There is compelling
evidence that the proteolytic processing of the amyloid precursor protein (APP) and …

Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations
are the most common cause of early onset familial Alzheimer's disease (FAD). In order to …

Importance Although considerable effort has been expended developing drug candidates
for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to safety …

Abstract Introduction Presenilin-1 (PSEN1) gene mutations are the most common cause of
familial Alzheimer's disease (fAD) and are known to interfere with activity of the membrane …

Summary Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1
transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ …

Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for
amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to …

Development of disease-modifying therapeutics is urgently needed for treating Alzheimer
disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β-and γ …

Mutations of the presenilin 1 (PS1) gene are the most common cause of early onset familial
Alzheimer disease (FAD). PS1 mutations alter the activity of the γ-secretase on the β …

Presenilin-1 (PS1) is the catalytic core of the aspartyl protease γ-secretase. Previous genetic
studies using germ-line deletion of PS1 and conditional knock-out mice demonstrated that …

The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset
familial Alzheimer's disease, harboring~ 300 causative mutations, and representing~ 90% of …