Autophagy is a process that maintains homeostasis during stress, although it also
contributes to cell death under specific contexts. Ceramides have emerged as important …

The role of autophagy in cancer is controversial. Melatonin has been linked to several
aspects of cancer progression and also to regulation of autophagy. Whether melatonin is …

Background Autophagy is considered to be another restorative focus for the treatment of
brain tumors. Although several research have demonstrated that melatonin induces …

AIM: To elucidate the effects of melatonin on cisplatininduced hepatocellular carcinoma
(HepG2) cell death and to identify potential cross-talk pathways. METHODS: Hepatocellular …

Even though an increasing number of anticancer treatments have been discovered, the
mortality rates of colorectal cancer (CRC) have still been high in the past few years. It has …

Autophagy modulation is a potential therapeutic strategy for tongue squamous cell
carcinoma (TSCC). Melatonin possesses significant anticarcinogenic activity. However …

Full article: Ceramide stress in survival versus lethal autophagy paradox Skip to Main Content
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Melatonin has protective roles in normal cells and cytotoxic actions in cancer cells, with
effects involving autophagy and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription …

Background Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of
human cervical cancer. Here, we explored the detailed molecular mechanisms played by …

Considering that chemotherapy resistance is vital to the progression of cervical carcinoma,
emerging researchers are focused on developing anti-tumor drugs to assist the treatment …