Transient receptor potential (TRP) ion channels in peripheral sensory neurons are
functionally regulated by hydrolysis of the phosphoinositide PI (4, 5) P2 and changes in the …

ON bipolar cells are critical for the function of the ON pathway in the visual system. They
express a metabotropic glutamate receptor (mGluR6) that, when activated, couples to the Go …

G-protein coupled receptors (GPCRs) govern the physiological response to stimuli by
modulating the activity of downstream effectors, including ion channels. TRPM3 is an ion …

Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a
sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor …

TRPM3 channels play important roles in the detection of noxious heat and in inflammatory
thermal hyperalgesia. The activity of these ion channels in somatosensory neurons is tightly …

The transient receptor potential (TRP) family of ion channels comprises receptors that are
activated by a vast variety of physical as well as chemical stimuli. TRP channels interact in a …

Opioids, agonists of µ-opioid receptors (µORs), are the strongest pain killers clinically
available. Their action includes a strong central component, which also causes important …

G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches
through which extracellular stimuli are transformed into intracellular effects, and it has long …

Transient Receptor Potential Canonical (TRPC) proteins form nonselective cation channels
commonly known to be activated downstream from receptors that signal through …

Activation of Gα q-coupled receptors by inflammatory mediators inhibits cold-sensing
TRPM8 channels, aggravating pain and inflammation. Both Gα q and the downstream …