Epigenetic mechanisms are able to alter gene expression, without altering DNA sequence,
in a stable manner through cell divisions. They include, among others, the methylation of …

Owing to the development of new technologies, the epigenome, a second dimensional
method for genome analysis has emerged. Epigenetic mechanisms, including DNA …

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information-containing factors, other …

Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …

A variety of osteoarticular conditions possess an underlying genetic aetiology. Large-scale
genome-wide association studies have identified several genetic loci associated with …

The sequence of the human genome represents our genetic blueprint. While it is now
possible to draw direct connections between specific DNA sequences and specific physical …

The availability of large human datasets for genome-wide association studies (GWAS) and
the advancement of sequencing technologies have boosted the identification of genetic …