Background The primary aim of our study was to evaluate the safety and potential toxicity of
gemcitabine combined with microbubbles under sonication in inoperable pancreatic cancer …

Purpose: The purpose of this study was to investigate the ability and efficacy of inducing
sonoporation in a clinical setting, using commercially available technology, to increase the …

This phase II trial was conducted to evaluate the safety and efficacy of concurrent
gemcitabine and high-intensity focused ultrasound (HIFU) therapy in patients with locally …

Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …

Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cause of cancer death
in the United States, with a median survival time of only 3− 6 months for forty percent of …

Background: Ultrasound (US) exposed microbubble (MB) contrast agents have the
capability to transiently enhance cell membrane permeability. Using this technique in cancer …

Purpose Adenocarcinoma of the pancreas remains one of the most lethal human cancers.
The high mortality rates associated with this form of cancer are subsequent to late-stage …

In this manuscript we describe the preparation of an oxygen-loaded microbubble (O 2 MB)
platform for the targeted treatment of pancreatic cancer using both sonodynamic therapy …

Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can
improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient …

Doxorubicin is a potent chemotherapeutic whose severe side effects limit its application.
Drug-targeted delivery with noninvasive techniques is required to increase the drug …