Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
C Germain, S Gnjatic, F Tamzalit… - American journal of …, 2014 - atsjournals.org
Rationale: It is now well established that immune responses can take place outside of
primary and secondary lymphoid organs. We previously described the presence of tertiary …
primary and secondary lymphoid organs. We previously described the presence of tertiary …
Long-term survival for patients with non–small-cell lung cancer with intratumoral lymphoid structures
MC Dieu-Nosjean, M Antoine, C Danel… - Journal of Clinical …, 2008 - ascopubs.org
Purpose It has been established that the immune system plays an important role in tumor
rejection. There is also compelling evidence that immune responses can develop …
rejection. There is also compelling evidence that immune responses can develop …
B cells and tertiary lymphoid structures influence survival in lung cancer patients with resectable tumors
J Tang, D Ramis-Cabrer, V Curull, X Wang… - Cancers, 2020 - mdpi.com
Simple Summary Nowadays, humans still die of lung cancer (LC), a disease mainly related
to cigarette smoking (CS). Smokers also develop chronic bronchitis, namely chronic …
to cigarette smoking (CS). Smokers also develop chronic bronchitis, namely chronic …
Tertiary lymphoid structure-B cells narrow regulatory T cells impact in lung cancer patients
C Germain, P Devi-Marulkar, S Knockaert… - Frontiers in …, 2021 - frontiersin.org
The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is
associated with better clinical outcome in many cancers. In non-small cell lung cancer …
associated with better clinical outcome in many cancers. In non-small cell lung cancer …
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality
W Zhu, C Germain, Z Liu, Y Sebastian, P Devi… - …, 2015 - Taylor & Francis
T and B cell receptor (TCR and BCR, respectively) Vβ or immunoglobulin heavy chain
complementarity-determining region 3 sequencing allows monitoring of repertoire changes …
complementarity-determining region 3 sequencing allows monitoring of repertoire changes …
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ …
J Goc, C Germain, TKD Vo-Bourgais, A Lupo, C Klein… - Cancer research, 2014 - AACR
Tumor-infiltrating T cells, particularly CD45RO+ CD8+ memory T cells, confer a positive
prognostic value in human cancers. However, the mechanisms that promote a protective T …
prognostic value in human cancers. However, the mechanisms that promote a protective T …
Tertiary lymphoid structures, drivers of the anti‐tumor responses in human cancers
MC Dieu‐Nosjean, NA Giraldo, H Kaplon… - Immunological …, 2016 - Wiley Online Library
The characterization of the microenvironment of human tumors led to the description of
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …
tertiary lymphoid structures (TLS) characterized by mature dendritic cells in a T‐cell zone …
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
De novo formation of tertiary lymphoid structures (TLS) has been described in lung cancers.
Intratumoral TLS seem to be functional and are associated with a long-term survival for lung …
Intratumoral TLS seem to be functional and are associated with a long-term survival for lung …
Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer
TA Zikos, AD Donnenberg, RJ Landreneau… - Cancer immunology …, 2011 - Springer
NSCLC arises in the complex environment of chronic inflammation. Depending on lung
immune polarization, infiltrating immune cells may either promote or suppress tumor growth …
immune polarization, infiltrating immune cells may either promote or suppress tumor growth …
[HTML][HTML] Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell …
X Sun, W Liu, L Sun, H Mo, Y Feng, X Wu… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Tertiary lymphoid structures (TLS) existence is correlated with favorable prognosis in many
types of cancer including non-small cell lung cancer (NSCLC). However, TLS formation and …
types of cancer including non-small cell lung cancer (NSCLC). However, TLS formation and …