A critical review on the opportunity to use placenta and innovative biomonitoring methods to characterize the prenatal chemical exposome

T Contini, R Béranger, L Multigner… - Environmental …, 2023 - ACS Publications
Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …

Analytical strategies to profile the internal chemical exposome and the metabolome of human placenta

R Al-Salhi, C Monfort, N Bonvallot, A David - Analytica Chimica Acta, 2022 - Elsevier
As a non-invasive biological matrix, the placenta offers great and novel opportunities to
monitor fetal exposure to exogenous chemicals and their biotransformation products (the …

[HTML][HTML] Pregnancy-related maternal physiological adaptations and fetal chemical exposure

MT Vinnars, M Bixo, P Damdimopoulou - Molecular and Cellular …, 2023 - Elsevier
Prenatal life represents a susceptible window of development during which chemical
exposures can permanently alter fetal development, leading to an increased likelihood of …

Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment

RC Fry, J Bangma, J Szilagyi, JE Rager - Toxicology and applied …, 2019 - Elsevier
During pregnancy, the placenta is critical for the regulation of maternal homeostasis and
fetal growth and development. Exposures to environmental chemicals during pregnancy can …

Environmental chemicals and adverse pregnancy outcomes: Placenta as a target and possible driver of pre-and postnatal effects

J Li, A Covaci, D Chen - Critical Reviews in Environmental Science …, 2023 - Taylor & Francis
Human placenta is key to fetal growth and development as it controls maternal-to-fetal
exchanges of endogenous and exogenous substances. Despite numerous studies have …

Review of the environmental prenatal exposome and its relationship to maternal and fetal health

JE Rager, J Bangma, C Carberry, A Chao… - Reproductive …, 2020 - Elsevier
Environmental chemicals comprise a major portion of the human exposome, with some
shown to impact the health of susceptible populations, including pregnant women and …

Fetal exposure to environmental chemicals; insights from placental perfusion studies

L Mathiesen, T Buerki-Thurnherr, J Pastuschek… - Placenta, 2021 - Elsevier
Introduction The burden of environmental chemicals in the human population is ubiquitous
and especially problematic in pregnancy due to potential exposure of the vulnerable fetus …

Environmental toxicants and placental function

MS Bloom, M Varde, RB Newman - Best Practice & Research Clinical …, 2022 - Elsevier
The placenta is a temporary endocrine organ that facilitates gas, nutrient, and waste
exchange between maternal and fetal compartments, partially shielding the fetus from …

Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix

Y Jeong, S Lee, S Kim, J Park, HJ Kim, G Choi… - Science of the total …, 2018 - Elsevier
The placenta is a crucial organ for the supply of oxygen and nutritional elements from
mother to fetus. Several studies have reported evidence of the placental transfer of …

[HTML][HTML] Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia

A Chao, J Grossman, C Carberry, Y Lai… - Environment …, 2022 - Elsevier
Background Environmental health research has recently undergone a dramatic shift, with
ongoing technological advancements allowing for broader coverage of exposure and …