Interactome analyses have traditionally been applied to yeast, human and other model
organisms due to the availability of protein–protein interaction data for these species …

Background A genomic catalogue of protein-protein interactions is a rich source of
information, particularly for exploring the relationships between proteins. Numerous systems …

Background As protein interactions mediate most cellular mechanisms, protein-protein
interaction networks are essential in the study of cellular processes. Consequently, several …

Background Protein-protein interactions play vital roles in nearly all cellular processes and
are involved in the construction of biological pathways such as metabolic and signal …

A major goal in systems biology is a comprehensive description of the entirety of all complex
interactions between different types of biomolecules—also referred to as the interactome …

Experimental high-throughput studies of protein–protein interactions are beginning to
provide enough data for comprehensive computational studies. Today, about ten large data …

Background The large-scale identification of physical protein-protein interactions (PPIs) is
an important step toward understanding how biological networks evolve and generate …

Protein interaction networks are important for the understanding of regulatory mechanisms,
for the explanation of experimental data and for the prediction of protein functions …

Background In the post-genomic era various functional genomics, proteomics and
computational techniques have been developed to elucidate the protein interaction network …

Background Protein-protein interactions are crucially important for cellular processes.
Knowledge of these interactions improves the understanding of cell cycle, metabolism …