Exome sequencing identifies potentially druggable mutations in nasopharyngeal carcinoma

YP Chow, LP Tan, SJ Chai, N Abdul Aziz, SW Choo… - Scientific reports, 2017 - nature.com
In this study, we first performed whole exome sequencing of DNA from 10 untreated and
clinically annotated fresh frozen nasopharyngeal carcinoma (NPC) biopsies and matched …

The genomic landscape of nasopharyngeal carcinoma

DC Lin, X Meng, M Hazawa, Y Nagata, AM Varela… - Nature …, 2014 - nature.com
Nasopharyngeal carcinoma (NPC) has extremely skewed ethnic and geographic
distributions, is poorly understood at the genetic level and is in need of effective therapeutic …

[HTML][HTML] Hotspot mutations in common oncogenes are infrequent in nasopharyngeal carcinoma

N Jiang, N Liu, F Yang, Q Zhou, R Cui… - Oncology …, 2014 - spandidos-publications.com
Oncogene mutations contribute to carcinogenesis and can provide potential therapeutic
targets for clinical anticancer management. However, oncogene mutation patterns in …

[HTML][HTML] Translational genomics of nasopharyngeal cancer

CM Tsang, VWY Lui, JP Bruce, TJ Pugh… - Seminars in cancer biology, 2020 - Elsevier
Nasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer
with strong etiological association with infection of the Epstein-Barr virus (EBV). With …

Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics

RB Ding, P Chen, BK Rajendran, X Lyu, H Wang… - Nature …, 2021 - nature.com
Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer type with high
morbidity in Southeast Asia, however the pathogenic mechanism of this disease is poorly …

Comprehensive genomic profiling of different subtypes of nasopharyngeal carcinoma reveals similarities and differences to guide targeted therapy

SM Ali, M Yao, J Yao, J Wang, Y Cheng, AB Schrock… - Cancer, 2017 - Wiley Online Library
BACKGROUND To date, no targeted therapy has been approved for nasopharyngeal
carcinoma (NPC), and this underscores the need for an in‐depth understanding of clinically …

Prognostic implications of a molecular classifier derived from whole‐exome sequencing in nasopharyngeal carcinoma

HY Wang, F Li, N Liu, XY Liu, XH Yang… - Cancer …, 2019 - Wiley Online Library
The aim of this study was to use whole‐exome sequencing to derive a molecular classifier
for nasopharyngeal carcinoma (NPC) and evaluate its clinical performance. We performed …

[HTML][HTML] Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma

J Si, B Huang, G Lan, B Zhang, J Wei… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
Background Nasopharyngeal carcinoma (NPC) is one of the most common cancers. To
investigate the gene mutation profile of NPC patients, we performed whole exome …

Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

YY Li, GTY Chung, VWY Lui, KF To, BBY Ma… - Nature …, 2017 - nature.com
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …

Oncogene mutational profile in nasopharyngeal carcinoma

ZC Zhang, S Fu, F Wang, HY Wang… - OncoTargets and …, 2014 - Taylor & Francis
Nasopharyngeal carcinoma (NPC) is a common tumor in Southern China, but the oncogene
mutational status of NPC patients has not been clarified. Using time-of-flight mass …